An antiviral drug, Valtrex is also marketed under its generic name, valacyclovir. It is designed to fight the herpes virus, which allows it to be used to treat chicken pox, shingles, as well as oral and genital herpes outbreaks. RxList notes that it is taken orally for initial outbreaks, recurrent outbreaks and preventative treatment cycles. Long-term Valtrex use comes the possibility of side effects which should be carefully watched.
Skin Irritation
Valtrex has been linked to skin irritation, a minor side effect that can persist or become more prevalent with long-term use. NetDoctor notes that the skin effects of Valtrex include rashes or itchiness, as well as a rash when skin is exposed to light, called photosensitivity. RxList also notes that in rare cases, patients may develop Stevens-Johnson syndrome, also called erythema multiforme, a full-body skin reaction to the drug.
Kidney Damage
Using Valtrex has been associated with kidney damage and is known to be taxing on the kidney, according to Drugs.com. In extreme cases, kidney damage can include problems that lead to acute renal failure, notes RxList. The effects of Valtrex on the kidneys have a cumulative effect over time. Minimizing this long-term effect of Valtrex can be accomplished by reducing dosage amounts, notes Drugs.com. Tests for kidney damage can also be ordered to monitor the situation.
Liver Damage
Another serious side effect of Valtrex that develops over time is liver damage. RxList notes that this may manifest in the form of liver enzyme abnormalities or in the development of hepatitis, or inflammation of the liver. Liver tests can be used to monitor liver health throughout the course of treatment.
Lowered Blood Platelet Counts
According to NetDoctor, long-term Valtrex use can result in a condition known as thrombocytopenia, which is an abnormally low platelet count. Drugs.com notes that patients using Valtrex should be especially vigilant for symptoms of thrombocytopenia, which include easy bruising or bleeding, bleeding of the mouth and gums, red splotches on the skin in a pinpoint spots pattern, and fever. Stopping Valtrex treatments may help, but extreme cases will require blood transfusions to restore platelet levels.
