People who experience chronic joint pain and inflammation due to osteoarthritis may experience relief from discomfort following treatment with methylsulfonylmethane or MSM. The efficacy and safety of MSM, a natural supplement, has not been clinically evaluated by the U.S. Food and Drug Administration. Before using this osteoarthritis treatment, people should discuss MSM supplement side effects with a medical professional.
Headache
People who take MSM may experience headache pain as a side effect of treatment, Drugs.com warns. Head pain can disrupt a person's ability to remain focused, attentive or alert during normal daily activities. People who develop recurrent head pain may alleviate discomfort through the use of an over-the-counter pain medication, such as acetaminophen.
Diarrhea
After taking a dose of MSM, people may develop diarrhea, which results in frequent, loose bowel movements. Diarrhea may also occur in conjunction with alternate abdominal side effects, including cramping, fullness, gas or pain. People who experience persistent diarrhea may be at risk of becoming dehydrated and should seek care from a doctor.
Upset Stomach or Nausea
An upset stomach may occur as a side effect of MSM in people, according to Kaiser Permanente. Upset stomach or nausea side effects may contribute to a loss of appetite in certain people. Consuming a small snack or meal before taking MSM can help limit or prevent upset stomach or nausea side effects.
Hypersensitive Reaction
Infrequently, people may experience a severe, hypersensitive reaction after taking MSM. Hypersensitive people may develop symptoms of dizziness, breathing difficulties, itching or oral swelling, Kaiser Permanente warns. People who experience this type of reaction require prompt medical attention in order to limit further medical complications.
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