Griffonia simplicifolia is derived from the seed of a west African plant. A source of 5-hydroxytryptophan (5-HTP), a precursor to serotonin, griffonia is an herbal remedy used to treat depression, fibromyalgia, migraines and headaches, insomnia and weight gain.
Depression
Some studies, such as a 1991 double-blind study overseen by Swiss researcher Dr. W. Poldinger, have documented improvement in individuals with mild to moderate depression who were treated with griffonia. Such studies, however, have not been large enough to provide conclusive, reliable evidence.
Fibromyalgia
Studies published in the "Journal of International Medical Research" in 1990 have likewise indicated improvement in the fibromyalgia symptoms of research participants who were being treated with griffonia. This is thought to be the result of a rise in serotonin levels. Still, not all participants experienced a relief of symptoms, and more studies have been called for to further examine whether there is a true benefit.
Insomnia
In a study published in the "Ann Med Psychol" of Paris, France, individuals who took 5-HTP in limited studies reported falling asleep faster and maintaining a deeper sleep than individuals who were given a placebo. Again, more testing is needed before these results can be considered conclusive.
Headaches
A 1987 study from Dr. F. Titus in the "Drugs under Experimental and Clinical Research Journal" measuring the effect of griffonia on sufferers of migraines and other headaches have yielded positive results. Research strongly suggests that children and adults experience some relief from the controlled use of 5-HTP.
Weight Loss
Results from weight loss studies from Dr. C. Cangiano and others in the "American Journal of Clinical Nutrition" have been more favorable. Study participants taking griffonia demonstrated more appetite control, eating fewer calories without trying to diet. More studies are being conducted to determine griffonia's efficacy as a weight loss treatment.
Safety & Side Effects
Side effects of using griffonia include nausea, flatulence and heartburn. Griffonia use has also been associated with a potentially fatal condition called eosinophilia myalgia syndrome. It is advisable that people considering using this supplement consult a physician first.
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