As a supplemental form of magnesium, magnesium orotate can help keep you going at optimal capacity. It fills vital roles producing energy and sustaining the health of your heart, muscles, bones and nerves. Magnesium and orotate both help build DNA. But you need to absorb magnesium before your body can use it, and orotate enhances absorption. Talk to your doctor before taking it, though -- the wrong dose of magnesium can cause side effects, particularly if you take medication.
Magnesium Orotate Overview
Magnesium orotate is produced by combining magnesium with orotic acid, which is a compound normally made inside your body and used to build DNA.
Orotic acid makes it easier for magnesium to cross cell membranes. As a result, your body can access more of the magnesium in magnesium orotate supplements, so you'll get more health benefits.
About 6 percent of a magnesium orotate tablet consists of elemental magnesium, which is less than many other chelated forms of magnesium, according to Global RPh.
Prevents Magnesium Deficiency
Magnesium orotate helps prevent a magnesium deficiency, which is important since many people consume less than the recommended dietary allowance. This type of suboptimal intake has been associated with Type 2 diabetes, high blood pressure and coronary artery disease, according to a report in Nutrition Reviews in March 2012.
Magnesium has an essential role in muscle contraction and nerve function. Your body needs it to produce proteins and DNA. You may feel sluggish if you don’t get enough magnesium because every cell depends on it to make energy.
To avoid low levels of magnesium, women should consume 310 milligrams to 320 milligrams daily, while men need 400 milligrams to 420 milligrams, reports the Office of Dietary Supplements.
Maintains Heart Health
Magnesium alone helps maintain a regular heartbeat, and when your supplement includes orotic acid, you may gain extra heart benefits. Some of the orotate is converted into substances that temporarily boost antioxidants and improve muscle activity in the heart, reported the scientific journal Open Heart in August 2014.
In an earlier study, patients with congestive heart failure who took magnesium orotate survived longer than patients who did not take supplements.
The study, which was published in May 2009 in the International Journal of Cardiology, also reported that symptoms improved in 39 percent of patients taking magnesium orotate, while symptoms worsened in 56 percent of the patients who took a placebo.
Builds Strong Bones
Magnesium is just as important for strong bones as vitamin D and calcium. Even though calcium contributes the mineral that builds bone, it can’t be absorbed into your system unless you have plenty of vitamin D, and synthesis of vitamin D depends on magnesium.
Researchers from Harvard Medical School and Vanderbilt University School of Medicine found that a high intake of magnesium significantly reduced the risk of vitamin D deficiency, according to their report published in BMC Medicine in August 2013.
Possible Side Effects
Magnesium consumed through supplements can pull extra water into the intestine and stimulate muscles in the colon wall. This means that high doses of magnesium orotate may cause diarrhea, nausea and abdominal cramping.
If you have kidney disease, a bleeding disorder or take any medications for diabetes, high blood pressure or a heart condition, talk to your doctor before taking magnesium orotate to be sure it’s safe for your health needs.
- MedlinePlus: Magnesium
- Human Metabolome Database: Orotic Acid
- The AFIB Report: Magnesium
- Global RPh: Magnesium Supplementation
- Nutrition Reviews: Suboptimal Magnesium Status in the United States: Are the Health Consequences Underestimated?
- Office of Dietary Supplements: Magnesium
- Open Heart: Beta-Alanine and Orotate as Supplements for Cardiac Protection
- International Journal of Cardiology: Magnesium Orotate in Severe Congestive Heart Failure (MACH)
- BMC Medicine: Magnesium, Vitamin D Status and Mortality: Results From US National Health and Nutrition Examination Survey (NHANES) 2001 to 2006 and NHANES III
- Analytical Research Labs: Chelated Minerals