Secretion of HGH
Human growth hormone is secreted by the somatrope cells of the anterior pituitary gland, located in the brain. HGH is released in a pulsing fashion at intervals throughout the day and night. The largest release of HGH occurs approximately one hour after falling asleep. Whether produced naturally or injected, the preferred method of synthetic HGH delivery, human growth hormone is next transported to the liver.
Liver
Though HGH can directly affect many receptors in body tissues, most of it is processed in the liver. Once in the liver, a portion of HGH is converted into IGF-1 or Insulin-like Growth Factor, as well as other important growth factors for tissue growth and regeneration. HGH reduces liver absorption of glucose and promotes gluconeogenisis, or the conversion of protein structure into glucose-like fuel for the body.
Roles in the Body
Both HGH and IGF-1 interact with receptors on tissues throughout the body. All of the major organs contain these receptors, including the brain. This may be the reason some claim abuse of synthetic HGH can cause growth of organ tissues. Tissues with the most receptors for HGH and IGF-1 include cartilage, bone and muscles. These growth factors align with osteoblasts or bone receptors to encourage calcium and mineral retention. In cartilage, the growth factors react with receptors called chondrocytes in order to stimulate growth. HGH and IGF-1 are also somewhat anabolic, encouraging the growth of muscle tissue. They also encourage lipolysis or fat burning.
Metabolizing HGH
HGH is broken down in the liver and kidneys. The liver can process between three to four IU of HGH every five to seven hours. For this reason, it's recommended that synthetic HGH users time their doses to mimic the body's natural means of metabolizing of this hormone. Exceeding this amount can cause side effects, and may not carry additional benefits. The liver and kidneys break down HGH into its basic amino acids, which are excreted in urine. Therefore, synthetic HGH use is difficult to detect and cannot easily be distinguished from supplementation with common amino acids.
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