Depression is a clinical mental illness that can have mental and physical effects. There are various treatments for depression, including talk therapy and prescription antidepressants; individual response to various therapies can vary. Some patients find relief through natural supplements, but these may not be effective for everyone. Prior to taking any supplements for depression, always consult with a health care professional to avoid adverse interactions with medications and health conditions.
5-Hydroxytryptophan
5-Hydroxytryptophan, or 5-HTP, is made from the amino acid tryptophan and is further converted to serotonin. Serotonin is a chemical in the brain involved with mood and behavior, and may also be associated with sleep, anxiety, appetite and pain sensations, according to the University of Maryland Medical Center website. The body cannot make 5-HTP naturally and the amount of this substance obtained from eating foods high in tryptophan is negligible. The UMMC notes that several studies have found 5-HTP to be as effective as some antidepressants for mild to moderate depression, but these studies had very small numbers of participants. More studies need to be performed to obtain definitive results. Side effects may include nausea, flatulence and heartburn. This supplement should not be taken with prescription antidepressant medications.
Omega-3 Fatty Acids
Omega-3 fatty acids are known for their beneficial effects on heart disease and their role as part of a healthy diet, but these substances may be helpful in easing depression symptoms, as well. Omega-3 fatty acids are essential acids, but they need to be consumed through food or supplements because the body does not produce them. These substances can be found in fish, like salmon or tuna, and in some oils and plants. The UMMC states that several studies have found that when individuals took omega-3 fatty acids with prescription antidepressants, depressive symptoms were relieved to a greater degree. Other studies have not found these results, so more evaluation needs to be done to explore this further. These supplements can also interfere with prescription medications.
St. John's Wort
St. John's wort is an herbal supplement commonly used to help treat depression. According to the National Center for Complementary and Alternative Medicine, this herb is thought to help depression by preventing nerve cells in the brain from reabsorbing serotonin, leaving more serotonin to improve mood, or by lowering the amount of a protein involved in the functioning of the immune system. It is also typically used for sleep disorders and anxiety. Studies on this supplement are mixed; some have found St. John's wort has beneficial effects in mild depression, while others found it as effective as a placebo, states the National Center for Complementary and Alternative Medicine. Side effects can include dry mouth, sensitivity to sunlight, nausea and diarrhea. Since this supplement may interfere with prescription medicines, including antidepressants, consult with a health care professional prior to taking it.
