Does DHEA Heal Adrenals?

Dehyrdoepiandrosterone, commonly known as DHEA, is a hormone produced primarily in the adrenal glands, with the brain and gonads secreting smaller amounts. Because DHEA regulates the production and function of 18 other hormones, it is considered a precursor hormone and has a complex role in a variety of bodily systems. DHEA production begins very early in life and gradually reaches a peak around the age of 25. DHEA levels decline steadily with age and, by age 75, the average human produces only 10 to 20 percent of their levels at age 25, according to "The Official Anti-aging Revolution" by Ronald Klatz and Robert Goldman.

Function of DHEA

The exact function of DHEA is complex and is still being explored. A study published in the June 1994 "Journal of Endocrinology and Metabolism" demonstrated the broad biological uses of DHEA. The researchers tested the effects of DHEA supplementation on 13 men and 17 women between the ages of 40 and 70. A control group received a placebo. After three months, 67 percent of the men and 82 percent of the women receiving DHEA reported a broad range of benefits including improved ability to cope with stress, quality of sleep and overall well-being.

These findings strengthen the theory that DHEA is converted into a number of hormones including testosterone, estrogen, progesterone and corticosterone.

Adrenal Disorders

The adrenal glands are small structures that sit atop the kidneys and help to regulate a number of biological responses including our ability to deal with stressful situations and sexual health. Disorders of the adrenal glands include pheochromocytoma, Cushing's syndrome, hyperaldosteronism and Addison's disease. These disorders are related to an excessive or deficient production of adrenal hormones. Because of the wide influence that adrenal hormones have on the body these disorders can be difficult to diagnose.

Potential of DHEA

The multiple influences of DHEA have led to theories regarding its usefulness in treating a variety of diseases. Studies are being conducted to find DHEA's effects on cancer, auto-immune diseases and cardiovascular disorders. According to the book "The Official Anti-Aging Revolution," "scientists speculate that if aging men and women can restore their DHEA to youthful levels, their youthful health and vigor will also be restored." DHEA has also been touted to be beneficial in the treatment of adrenal diseases.

Expert Insight

A study reported in the February 2008 "Journal of Endocrinology and Metabolism" tested the effects of DHEA replacement therapy on Addison's disease, which causes deficiencies in adrenal hormones, over a 12-month period. The researchers concluded that their "results support some beneficial effects of prolonged DHEA treatment in Addison's disease."

These results suggest that DHEA may be beneficial for other adrenal disorders, but further research is needed.

Warning

DHEA supplements are readily available, but overuse can restrict natural production of DHEA by the body. Large doses of DHEA may cause liver damage. Men with prostate cancer, women with ovarian cancer, pregnant women and children should not take DHEA. Always consult your doctor before beginning supplementation.