Polyethylene glycol 3350 (PEG 3350) is a drug used to treat constipation. This drug is sold under the brand name MiraLax. Because this medication works to relieve constipation, it can cause several side effects. While some do not have harmful lasting effects, others should be reported to a medical professional immediately.
Digestive System
Since polyethylene glycol 3350 produces a laxative effect, digestive system side effects are the most common. According to the National Institutes of Health, users may experience nausea, flatulence, abdominal cramps and bloating. Diarrhea can also occur as a side effect of PEG 3350 and should be reported to a physician or nurse-practitioner. Persistent diarrhea can lead to dehydration and electrolyte imbalances, which can have serious consequences.
Electrolyte Imbalance
If too much of this drug is taken, it can cause an electrolyte imbalance to develop. This occurs as the result of the loss of water from the body. Polyethylene glycol 3350 can cause the loss of sodium, potassium, calcium and other electrolytes. If the signs and symptoms of electrolyte imbalance occur, contact a medical professional immediately. The University of Florida Shands Cancer Center indicates that muscle spasm, twitching, weakness, confusion, numbness, blood pressure changes, convulsions, irregular heartbeat, seizures and lethargy are signs and symptoms of an electrolyte imbalance.
Worsened Medical Conditions
It is important to inform your doctor about your past medical history before taking polyethylene glycol 3350. Taking this drug can make existing medical conditions worse, so some patients may not be able to take this drug for constipation. Alert your doctor to any history of kidney disease, irritable bowel syndrome, persistent abdominal pain or persistent nausea and vomiting. This drug should not be taken by anyone with a history of bowel obstruction.
Allergic Reaction
Allergic reaction to PEG 3350 is rare, but it is a possible side effect of taking the drug. Consult a medical professional immediately if rash, hives, itching or swelling of the face, tongue and lips occur. These are signs of a serious allergic reaction, which can cause problems with breathing or maintaining normal heart function. Mild allergic reactions can be treated with antihistamines that relieve itching, rashes and hives. If anaphylaxis occurs as a result of the allergy, an epinephrine injection may be given. Corticosteroids and bronchodilators can also be used to treat some of the signs of allergic reaction to PEG 3350.
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