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Negative Side Effects of Paba

author image Leigh Wittman
Leigh Wittman has been writing professionally since 2007. She writes primarily on health, career advice, outdoor pursuits and travel for various websites. Wittman is a licensed nurse and studied nursing at Arizona State University.
Negative Side Effects of Paba
A mother is applying sunscreen to her child's face. Photo Credit Jupiterimages/Stockbyte/Getty Images


PABA -- para-amino-benzoic acid -- is used in a variety of ways, including topically as a reflective agent in many commercial sunscreens and orally to darken the hair of the elderly and treat constipation and vitiligo, which is a loss of pigmentation of random spots on the skin, according to "Foundations of Nursing." Side effects of PABA vary depending on the duration of exposure, route of administration and dosage.

Liver Damage

When PABA is administered orally, it can have harmful effects on the liver, according to "Foundations of Nursing." According to "Introduction to Medical-Surgical Nursing," the liver is affected when PABA is consumed in amounts equal to or greater than 8g. When this amount of PABA is consumed, the liver loses its ability to function properly, which can ultimately lead to liver failure, according to "Foundations of Nursing." Liver failure leads to death without prompt medical care, according to "Introduction to Medical-Surgical Nursing."

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Skin Abnormalities

"Clinical Dermatology" says that PABA can lead to a variety of skin abnormalities when applied topically, ranging from discoloration to cancer. Typically, PABA is applied topically when using sunscreen, according to "Foundations of Nursing." PABA protects against carcinoma but does not protect the skin from melanoma, according to "Clinical Dermatology." Additionally, PABA contributes to the release of oxygenated free radicals, which "Clinical Dermatology" says can lead to deepened skin pigmentation in the best of cases and skin cancer in the worst of cases.

Allergic Reactions

Like all chemicals, it is possible to be allergic to PABA, according to "Foundations of Nursing." Allergic reactions vary based about the amount, duration and route of exposure, according to "Introduction to Medical-Surgical Nursing." When applied topically, PABA can cause skin redness, irritation and itching, according to "Clinical Dermatology." When ingested orally, PABA can result in dizziness, gastrointestinal upset and respiratory distress, according to "Introduction to Medical-Surgical Nursing."

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  • “Foundations of Nursing”; Lois White, Gena Duncan and Wendy Baumle; 2010
  • "Introduction to Medical-Surgical Nursing"; Adrianne Dill Linton; 2007
  • "Clinical Dermatology"; Richard Weller, John A. Hunter, John Savin and Mark Dahl; 2008
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