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Side Effects of Magnesium Trisilicate

author image Rae Uddin
Rae Uddin has worked as a freelance writer and editor since 2004. She specializes in scientific journalism and medical and technical writing. Her work has appeared in various online publications. Uddin earned her Master of Science in integrated biomedical sciences with an emphasis in molecular and cellular biochemistry from the University of Kentucky College of Medicine.
Side Effects of Magnesium Trisilicate
Pile of different colored antacid tablets Photo Credit Ryan Mackay/Hemera/Getty Images


If you experience recurrent episodes of heartburn or indigestion, your doctor may recommend treatment with an antacid called magnesium trisilicate. Typically, magnesium trisilicate is used in conjunction with another antacid called aluminum hydroxide to neutralize acid in your stomach. Magnesium trisilicate is administered orally as a chewable tablet and should only be taken as recommended by a medical professional. Talk with your doctor about the side effects of magnesium trisilicate before beginning treatment with this antacid.

Bowel Movement Changes

You may develop bowel movement changes as a side effect of taking magnesium trisilicate. Difficult, infrequent or absent bowel movements—a side effect called constipation—can be uncomfortable and may contribute to abdominal bloating or pain. This medication may also induce frequent bowel movements that yield watery or loose stools. Diarrhea may also be accompanied by excessive flatulence or belching, notes the Patient UK website. If bowel movement changes persist, seek care from a medical professional.

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Upset Stomach

This type of antacid may irritate your digestive tract. You may experience sensations of nausea or you may vomit. Stomach discomfort may result in the loss of your normal appetite. Talk with your physician if upset stomach side effects become severe or do not subside with continued use of magnesium trisilicate.

Muscle Weakness

Excessive or prolonged treatment with antacids that contain magnesium trisilicate may elevate the amount of magnesium in your blood. If this occurs, you may experience sensations of muscle weakness as a side effect of treatment. Muscle weakness may affect your ability to perform normal daily activities, such as lifting a grocery bag or climbing a flight of stairs. Seek care from a medical professional if you experience sudden or severe weakness, as these side effects may also be signs of alternative health issues, such as a stroke or multiple sclerosis.

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