Vitamin D supplements present the risk of side effects as with most other supplements. Vitamin D supplements are taken to correct a vitamin D deficiency, prevent a deficiency, improve absorption of calcium or for disease prevention. Dosage varies from 400 IU to 50,000 IU. The higher the dose, the higher the risk for side effects. A 1,000 IU vitamin D supplement is a standard dose of vitamin D and comes with a low risk for side effects. However, knowledge of side effects prior to starting a supplement is prudent to prevent any adverse events. Supplement use is recommended under the supervision of a physician.
Overdose
Vitamin D supplement overdose could occur, though rare. The side effects of an overdose include weakness, weight loss, muscle pain, bone pain, constipation, nausea, vomiting or a metallic taste in the mouth according to Drugs.com.
Behavior and Mood
Side effects may include symptoms associated with behavior and mood from taking vitamin D. Once again, this would be rare. It is best to stop taking vitamin D and call a doctor if symptoms related to thinking problems, behavior changes and irritability arise.
Toxicity
Toxicity of vitamin D is an unlikely occurrence, especially at 1,000 IU, but should be taken seriously. A study in the 2001 "American Journal of Clinical Nutrition" explains that doses less than 10,000 IU are safe and toxicity symptoms are rarely seen. The Merck Manual explains levels of 50,000 IU taken for months can cause a toxicity with possible symptoms of anorexia, nausea, vomiting, weakness, nervousness and renal failure. Protein in the urine, waste products in the blood and calcifications in the kidney may develop, according to the Merck Manual.



Member Comments