For years, Pacific Islanders have used the roots of Piper methysticum, or kava kava, for both medicinal and ceremonial purposes. Kava kava is a large shrub that grows in the islands of the Pacific and purportedly treats anxiety, nervous disorders and insomnia. Despite its possible benefits, kava kava may cause life-threatening side effects. You should never take this or any other herbal supplement without discussing it with your physician first.
Kava Kava
Kava is a large shrub that grows in the Pacific Islands and is characterized by large, heart-shaped green leaves, long slender flowers and thick hairy branches. Pacific Islanders have used kava as a ceremonial drink for hundreds of years because of it relaxation effects, reportedly similar to those of alcohol.
Uses
Herbalists commonly grind the shrub's root for medicinal use to treat epilepsy, migraines, psychosis, anxiety, insomnia, chronic tuberculosis, chronic fatigue syndrome and muscle pain, according to the University of Maryland Medical Center. Some people also use kava as an ointment to promote wound healing and reduce pain in skin diseases such as leprosy.
Liver Toxicity
In November of 2002, the FDA issued a consumer warning stating that 11 patients who used kava kava supplements had experienced total liver failure and subsequently undergone liver transplants. Liver-related risks associated with the herb have caused countries such as Switzerland, Canada, France and the United Kingdom to issue warnings on products containing kava or remove them from shelves entirely, according to the Centers for Disease Control and Prevention. The National Institutes of Health explains that kava kava is likely unsafe when taken by mouth and encourages people not to use it.
Drug Interactions
Kava kava works by affecting the central nervous system, and this can increase the effects of anesthesia, benzodiazepines and central nervous system depressants. Kava kava also affects drugs that are changed by the liver, such as antipsychotic medications, diazepam, glipizide, torsemide and many others. Kava's potential to harm the liver means that taking it with other medications that can also cause liver problems, such as acetaminophen, amioderone and methotrexate, can potentiate these effects.
Considerations
People should not take kava kava without a physician's supervision. If you have cirrhosis, hepatitis or any other liver damage, you should not take kava kava. The FDA does not regulate the safety, purity or effectiveness of herbal supplements, and some may contain traces of toxic metals.
References
- Food and Drug Administration: Kava-Containing Dietary Supplements May be Associated With Severe Liver Injury
- Centers for Disease Control and Prevention: Hepatic Toxicity Possibly Associated with Kava-Containing Products --- United States, Germany, and Switzerland, 1999---2002
- National Institutes of Health: Kava
- University of Maryland Medical Center: Kava Kava



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