Calcium D-glucarate is a form of D-glucaric acid that is bound to calcium to form a salt. D-glucaric acid is a naturally occurring chemical present in many types of fruits and vegetables, including apples, broccoli, Brussels sprouts, bean sprouts and cabbage. Preliminary research suggests that calcium D-glucarate may reduce the risk of cancer, although there is not enough evidence to certify this claim. No side effects caused by calcium D-glucarate have been reported, but consult your doctor before starting any new health supplements.
No Reported Side Effects
Although no large clinical trials in humans have thoroughly investigated the safety of calcium D-glucarate, no side effects have been reported by people taking the supplement, according to the University of Michigan Health System. Still, consult your doctor before adding it or any other supplement to your diet.
Potential Hormone Interaction
Based on the chemical properties of calcium D-glucarate, it could theoretically interact with estradiol, a form of the female sex hormone estrogen, according to the Memorial Sloan-Kettering Cancer Center. Estradiol is often used in oral birth control or hormone replacement therapy, and taking calcium D-glucarate could potentially reduce the effectiveness of these treatments.
Potential Drug Interactions
The chemical properties of calcium D-glucarate also suggest that it could theoretically cause the liver to metabolize certain drugs at a faster rate -- particularly the drug entacapone, which is used to treat Parkinson's disease, the Memorial Sloan-Kettering Cancer Center says. When drugs are metabolized and excreted from the body at a faster rate, their effectiveness is reduced, potentially worsening disease symptoms.
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