An over-the-counter bodybuilding supplement, N.O.-Xplode is touted as an "Extreme Pre-Training Igniter" by its manufacturer, BSN. It is sold as a powder available in various flavors to be combined with water and consumed before an intense workout in order to promote blood flow for a more intense "pump." If you are currently using or plan on using N.O.-Xplode, it is vital that you understand the supplement's key side effects to watch out for.
Mild Side Effects
The National Institutes of Health report that side effects from L-arginine -- the active ingredient in N.O.-Xplode -- tend to be rare and mild. Some mild side effects to look out for when using N.O.-Xplode include abdominal pain, bloating, and inflammation of airways. Although these symptoms are rare, it is a good idea to mention them to your doctor if you experience any while using N.O.-Xplode.
Serious Side Effects
Rare but serious side effects of N.O.-Xplode to watch for include gout and low blood pressure. This is because of the supplement's large content of L-arginine, which, when converted within the body to nitric oxide, acts as a vasculodilator -- widening blood vessels throughout the body. In a 2010 study listed on the National Library of Medicine's PubMed website, vasculodilator supplements such as N.O.-Xplode -- when used as athletic performance enhancers -- have been linked with cardiovascular collapse, which can result in coma and even death. Although this side effect is very rare, it is nevertheless crucial to discuss with your physician.
Pre-existing Conditions and Side Effects
N.O.-Xplode may decrease blood pressure, so talk with your doctor before taking the supplement if you have low blood pressure. High levels of L-arginine may also exacerbate cold sores and herpes by stimulating replication of the virus, reports the University of Michigan Health System. Also, if you have asthma, taking N.O.-Xplode may worsen your symptoms. If you are pregnant or breastfeeding or have any of the above medical conditions, it is crucial that you consult with your physician before taking N.O.-Xplode.
Adverse Interactions
N.O.-Xplode may also interact adversely with certain medications, leading to unpredictable side effects. Do not take N.O.-Xplode without first consulting with your physician if you are taking any high blood pressure medications. Combining N.O.-Xplode with nitrates for heart disease can lead to symptoms such as dizziness and feeling lightheaded. If you take erectile dysfunction medication sildefanil, or Viagra, avoid taking N.O.-Xplode since the supplement and the medication both increase blood flow.
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