Glucosamine is a naturally occurring substance in your cartilage, the tough tissue that serves as a cushion between your joints. If you experience chronic joint discomfort from a medical condition like osteoporosis, you might benefit from taking glucosamine HCl supplements, which might help reduce pain, inflammation and stiffness. However, glucosamine HCl can be dangerous for some people. Talk with your medical provider before you begin treatment with this joint health supplement.
Side Effects
Treatment with glucosamine HCl might induce stomach-related side effects, such as nausea, heartburn, bloating and gas, the University of Maryland Medical Center reports. You also might experience urgent or frequent watery bowel movements. Diarrhea can be uncomfortable and can exacerbate stomach discomfort. Consider eating a small snack before taking supplements that contain glucosamine to help reduce or limit stomach discomfort. Consult your medical provider if you experience chronic diarrhea, which can be dangerous because it can lead to dehydration.
Allergic Reaction
Glucosamine HCl supplements might be derived from shellfish. The supplement facts for this type of glucosamine supplement generally contains an allergen warning noting that the supplement might contain shellfish. If you have a shellfish allergy, taking glucosamine HCl derived from shellfish could cause a life-threatening allergic reaction called anaphylaxis. Seek emergency medical care if you experience shortness of breath, difficulty swallowing, severe itching, weakness or facial swelling. Vegan glucosamine supplements, which are derived from corn, provide an alternative source.
Medication Interactions
Talk with your physician about any medication you are taking before you begin treatment with this supplement. Glucosamine HCl can interact with a number of medications, such as certain types of chemotherapy medications, diabetes drugs, blood thinners and acetaminophen, RxList warns. If you use any of these medications in conjunction with glucosamine HCl, you can be at risk of developing more severe side effects, such as increased blood sugar, bruising or bleeding.
Precautions and Contraindications
People with diabetes should not take glucosamine HCl unless directed by a medical professional, as treatment with this supplement can alter blood sugar levels. Consult your doctor before using this supplement if you are scheduled to have surgery within the next few weeks. Additionally, the safety and efficacy of this supplement have not been adequately studied in pregnant women. If you are pregnant or breastfeeding, avoid taking glucosamine HCl supplements to limit your risk of experiencing unintended pregnancy complications.



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