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Foods That Interfere With Blood Pressure Medication

author image Karla Casco
Karla Casco began writing in 2010, focusing her work on diseases and treatments and their side effects. She has also created patient handouts, PowerPoint presentations and journal clubs. Karla has a doctorate in pharmacy from St. John's University and holds a pharmacy license for the state of New York.
Foods That Interfere With Blood Pressure Medication
Grapefruit for sale at a market. Photo Credit federicofoto/iStock/Getty Images


Prescription medications are generally safe and effective, but many of them can interact poorly with certain foods. Blood pressure medications are one example of drugs that can be affected by the food you eat. Speak to your physician or pharmacist about what foods you should avoid if you're taking blood pressure medication. If you start a diet plan, speak with your physician to make sure it is safe.

Grapefruit Juice

Foods That Interfere With Blood Pressure Medication
Grapefruit for sale at a market. Photo Credit federicofoto/iStock/Getty Images

Grapefruit and grapefruit juice may interact with a class of antihypertensive drugs called the calcium channel blockers, or CCBs. These include amlodipine, felodipine, verapamil, nifedipine, isradipine and nicardipine. CCBs are not the preferred treatment for high blood pressure, but they are effective at lowering blood pressure when other medications have failed. The breakdown of the CCBs may be blocked by grapefruit juice, leading to an increase in the amount of medication in the blood. Large amounts of grapefruit juice increase the effect of the medications, according to “Pharmacotherapy: A Pathophysiologic Approach.” This may lead to an increase in medication side effects and toxicity effects. Grapefruit and grapefruit juice should be avoided if you take a calcium channel blocker.

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Foods with Potassium

Amiloride is a potassium sparing diuretic used to prevent a decrease in your potassium level by other diuretics, such as furosemide, in the treatment of hypertension. The “Drug Information Handbook” explains that foods that contain potassium may cause hyperkalemia, which is a dangerously high potassium level. Foods that are high in potassium include bananas, cantaloupe, grapefruits, oranges, tomato juice, prunes, honeydew melons, molasses and potatoes. Consume few or none of these potassium-rich foods while taking amiloride. Ask how much potassium you can ingest daily. If your potassium level is high, your physician may adjust the dose of your diuretics and blood pressure medication.

Protein-Rich Foods

Propanolol is a beta-blocker used in the treatment of high blood pressure, as well as chest pain and irregular heartbeat. A diet that is high in protein may increase the rate at which propranolol is absorbed by the body, and this may lead to an increased affect of the medication. Many foods contain protein, including meat and dairy products. If your diet is high in protein, speak with your physician or pharmacist to make sure the food will not interfere with your medications. Ask your physician which foods you can eat with your dosage of propranolol.

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  • "Pharmacotherapy: A Pathophysiologic Approach"; Joseph T. Dipiro, Robert L. Talbert, et al.; 2008
  • "Drug Information Handbook"; Charles F. Lacy, Lora L. Armstrong, et al.; 2009
  • American Heart Association: Potassium
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