Injections of vitamin B-12, also known as cyanocobalamin, are used to treat and prevent vitamin B-12 deficiencies. Vitamin B-12 is important for the production of healthy red blood cells, DNA synthesis and maintenance of healthy nerve cells. Vitamin B-12 is absorbed from foods in the stomach and intestines. If you have had surgery to remove part of your stomach or intestines, you may be at risk for a B-12 deficiency and may be treated with B-12 shots.
Skin Irritation
Vitamin B-12 is injected into a muscle under the skin. You may experience pain, redness and swelling at the injection site immediately after the injection. These reactions are normal. However, if you notice unusual warmth and discharge at the injection site, inform your doctor, as these may be signs of an infection.
Gastrointestinal Disturbances
You may experience minor gastrointestinal disturbances such as nausea, upset stomach and diarrhea after receiving B-12 injections. These side effects go away after continued treatment. If you notice worsening of gastrointestinal symptoms, consult your doctor, as you may be experiencing a serious allergic reaction to B-12 shots.
Other Effects
You may experience common nervous system side effects such as headache, dizziness, weakness, numbness and tingling of your extremities, according to Drugs.com. Some patients may experience adverse side effects such as blood clots, heart failure and serious allergic reactions. If you experience these adverse side effects, seek immediate medical attention.



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