Sitrex is an oral prescription medication that combines guaifenesin and phenylephrine. Guaifenesin is an expectorant used to thin and loosen the mucus in the airways while phenylephrine is a decongestant that reduces nasal congestion by narrowing the blood vessels in the nose and sinuses. This medication, used to treat upper respiratory conditions including the common cold, allergies, bronchitis, asthma and sinusitis, can induce a variety side effects.
Initial Effects
Sitrex rarely induces digestive upset including nausea, stomach upset, cramps, vomiting or diarrhea. If you do experience these side effects, the package insert recommends you avoid crushing the pills and take them with either food or milk to minimize these effects.
Sitrex may also cause headache, dizziness, drowsiness and nervousness that can lead to trouble sleeping.
Severe Effects
Oral decongestants such as phenylephrine act on the blood vessels throughout the body, thereby inducing unwanted side effects. Narrowing of the blood vessels can cause an increase in blood pressure, tachycardia (rapid heartbeat), urinary retention and hyperglycemia (increased blood sugar levels).
Other rare but serious side effects include tremors (shaking), irritability, confusion and hallucinations. If you experience any of these side effects, contact your doctor immediately.
Allergic Reactions
The occurrence of an allergic reaction to Sitrex is rare, but possible. Symptoms of an allergic reaction include rash, itching or swelling of the face, tongue or throat, severe dizziness and difficulty breathing.



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