Glucosamine is a compound found naturally in the tough tissues of the joints, called the cartilage, and is available as glucosamine hydrochloride, a salt form of glucosamine. The supplement may be purchased in a pharmacy or drug store and may come in tablet, capsule or powder form. Glucosamine may be beneficial for certain conditions, but you should speak with your physician before starting any over-the-counter product to ensure its safety for you.
Uses
Glucosamine HCl is able to treat osteoarthritis, the inflammation of the joints that causes pain, stiffness and swelling. Glucosamine HCl reduces osteoarthritic pain, swelling and joint stiffness. It may also improve function in individuals with pain and swelling in the knee or hip. Other uses, such as ulcerative colitis and Crohn's disease, require further studies to determine if glucosamine has any benefit.
Side Effects
Glucosamine is safe for most adults and is well-tolerated. Glucosamine hydrochloride can lead to gastrointestinal side effects, such as stomach upset, gas, bloating, and diarrhea. Taking the product with food may help. If these side effects worsen, discontinue the medication and speak with your physician.
Drug Interactions
Glucosamine has a major interaction with warfarin, a blood thinner. It increases the effect of warfarin in the body and may increase the risk of bleeding. If you take warfarin, do not take glucosamine hydrochloride. Some medications used to treat cancer may interact with glucosamine, as well. Glucosamine may increase the rate at which tumor cells copy themselves and therefore, decrease the effect of cancer medications. Many individuals with osteoarthritis take nonsteroidal anti-inflammatory drugs, NSAIDs, to treat the symptoms. Since glucosamine can alleviate the symptoms of osteoarthritis, you may require a lower dose of your medication. Glucosamine may also change the dose of medications used for medications, such as glyburide, metformin and insulin. Speak with your health care provider if you wish to take glucosamine to avoid drug interactions.
Warnings
Glucosamine hydrochloride is produced from shellfish, including shrimp, lobster and crabs. If you have an allergy to shellfish, you should avoid the use of any glucosamine products. If you develop an allergic reaction after taking glucosamine, seek medical help right away. Allergic reactions include a skin rash, itchiness, redness, difficulty breathing and chest pain.
Glucosamine may come in different strengths; try to take the same dose and product to avoid variations in how it affects you. Always follow the directions on the label and do not take more than the recommended dose. If you are unsure of which product or dose to use, speak with your physician or pharmacist.
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