Glucosamine is a natural substance found in the joints and the fluid around the joints. In North America, glucosamine is also available as an over-the-counter supplement, usually derived from seashells. This supplement has been widely researched for treating arthritis. According to RxList.com, glucosamine is as effective as some conventional drugs for pain relief in osteoarthritis, although it may take longer to see results. Glucosamine appears to help in cases of rheumatoid arthritis as well; however, more research is needed to confirm its benefits for this particular condition. If you suffer from rheumatoid arthritis and are considering taking glucosamine, talk to your doctor first.
Research
Glucosamine has been shown to improve symptoms in patients suffering with rheumatoid arthritis, according to the results of a study published in the September 2006 issue of "Rheumatology International." This double-blind placebo-controlled study showed a remarkable decrease in pain and swelling associated with rheumatoid arthritis when glucosamine was used at a dose of 1,500 mg per day. However, authors noted that blood tests did not reveal significant changes in the markers of inflammation.
Dosage
The daily dose recommendations of glucosamine for improving symptoms of rheumatoid arthritis in adults is 500 mg of glucosamine sulfate or glucosamine hydrochloride, three times a day. Another option is a single daily dose of 1,500 mg. For best results, you should use glucosamine for at least three to six months. This dosage may be adjusted based on the severity of your symptoms, other medical conditions that you may have, and whether you use other drugs or herbs.
Safety
Side effects such as stomach upset, diarrhea, bloating, indigestion and heartburn have been reported, but these may be eliminated if you take this supplement with food. If you suffer from rheumatoid arthritis and you also have diabetes, you should cautiously use glucosamine because this supplement may reduce the efficacy of insulin and oral anti-diabetes drugs. Pregnant and breastfeeding mothers are not advised to use glucosamine because limited research has been conducted to evaluate the safety of glucosamine during pregnancy and lactation. Glucosamine also may interact with nonsteroidal anti-inflammatory drugs.
Considerations
Consult a qualified health care provider to find out the optimal dosage of glucosamine that may help improve your condition. Glucosamine should not be used to replace any medication you are currently taking. The U.S. Food and Drug Administration has not approved glucosamine for the treatment of rheumatoid arthritis.
References
- RxList.com: Glucosamine
- MayoClinic.com: Glucosamine
- "Rheumatology International"; Effects of Glucosamine Administration on Patients With Rheumatoid Arthritis; H. Nakamura et al.; September 2005
- University of Maryland Medical Center: Glucosamine
