Grape seed extract, or GSE, is an alternative treatment studied for its effects on certain medical conditions, as well as its ability to prevent cell damage. According to the Memorial Sloan-Kettering Cancer Center, certain side effects are associated with using dietary supplements that contain grape seed extract.
GSE
Like the name suggests, GSE is derived from grape seeds, and is sold in capsule and tablet preparations. GSE is sometimes used to treat chronic venous insufficiency, edema, high blood pressure and diabetic retinopathy, according to the National Center of Complementary and Alternative Medicine, or NCCAM. GSE also contains antioxidants that may prevent cell damage caused by free radicals. As of January 2011, the NCCAM intended to fund studies to determine if GSE can be beneficial in preventing certain types of cancer, Alzheimer's disease and other brain disorders, as well as its effect on the heart.
Side Effects
According to the NCCAM, clinical trials suggest that GSE is generally safe when taken for eight weeks at a time. Side effects reported during clinical trials include nausea, indigestion, headache, hives, high blood pressure and an itchy, dry scalp.
Interactions With Medications
The interaction between GSE and other medications and dietary supplements hasn't been thoroughly studied. However, the Memorial Sloan-Kettering Cancer Center indicates that theoretically, GSE can increase your risk of bleeding and should not be used concomitantly with blood-thinning medications such as warfarin.
Cautions
The U.S. Food and Drug Administration classifies GSE as a dietary supplement, which means that the efficacy, safety and quality of your product is not assured. Dietary supplements do not go through the same stringent approval process as prescription and nonprescription drugs. Dietary supplements of any kind may be dangerous if you're pregnant, nursing, suffer from certain health conditions or take medications and other dietary supplements. Talk to your doctor before using GSE to address your health concerns.



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