Accuzyme is the brand name of papain-urea topical solution. Papain is derived from papaya fruit. According to Drugs.com, papain and urea are used to break down certain proteins. Accuzyme can be applied to dead skin or tissues that are wounded to assist in the debridement of the tissues. Drugs.com explains that the breaking down of the wound tissues assist in the healing process. As with any medication, Accuzyme has the potential for side effects. The FDA issued a statement in November 2008 that products containing papain, including Accuzyme, should not be used, manufactured or distributed.
Common Side Effects
Most users do not experience any side effects with the use of Accuzyme. The most commonly occurring side effects are mild and may include stinging or burning where the medication is applied.
Serious Side Effects
The FDA points out that the risk of hypersensitivity in users can lead to serious side effects like low blood pressure and rapid heart rate. Emergency room treatment may be necessary due to the severity of these side effects.
Signs of Allergy
In the event that a user is allergic to the ingredients in the topical solution, a mild to severe reaction may occur. Signs of allergy may include hives, difficulty breathing, swelling of the face, swelling of the lips, and swelling of the tongue and/or throat. Drugs.com says that medical attention is required if an individual experiences this type of reaction, because it can lead to asphyxiation. The FDA made the statement stopping the distribution of papain products primarily because of serious allergic reactions in users that resulted in emergency room treatment. Individuals with latex allergies may also be allergic to papain, as indicated by FDA.gov.
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