The fruit of the cayenne plant, which is native to South America, may provide health benefits when used medicinally. The spicy flavor and medicinal properties of cayenne come from a substance called capsaicin. Topical or oral treatment with cayenne may help alleviate pain and inflammation. Before using this natural supplement, be sure to discuss the side effects of using cayenne with your medical provider.
Skin Inflammation
When applying a topical cayenne cream that contains capsaicin, your skin may temporarily burn or tingle. Skin inflammation or irritation may lead to itching. Be sure to cleanse your hands with vinegar after applying cayenne cream to remove the capsaicin oil from your hands. Washing your hands in water may still leave capsaicin residue on your hands and may cause further irritation if you touch your face or eyes with contaminated hands. Stop using cayenne cream and seek additional care from your doctor if skin inflammation does not subside or becomes severe.
Stomach Irritation
Orally-administered cayenne supplements may irritate your stomach or digestive tract. You may develop a burning sensation in your mouth that may cause your eyes or nose to run. Consuming too much cayenne may severe stomach inflammation -- a condition called gastroenteritis -- which may result in diarrhea, vomiting, abdominal pain, fever or chills. Long-term treatment with this supplement should be avoided as it may result in liver or kidney damage. Consult your doctor if you experience severe stomach pain or symptoms of liver or kidney damage, such as jaundice, fatigue or itchy skin. If you have a pre-existing stomach condition, such as heartburn or a stomach ulcer, talk with your doctor before consuming cayenne.
Allergic Reaction
If you're allergic to kiwi, chestnuts, avocado, bananas or latex, you may be at an increased risk of experiencing an allergic reaction after ingesting cayenne, the University of Maryland Medical Center warns. Allergic reaction symptoms include facial swelling, hives, difficulty swallowing, trouble breathing and pale skin. Emergency medical care is required if such symptoms arise. Without appropriate treatment, an allergic reaction to cayenne may be life-threatening.
Drug Interactions
Discuss all medications you are taking with your health care provider before consuming cayenne. Do not use topical creams that contain capsaicin if you are also taking and ACE inhibitor, a medication that helps lower high blood pressure. Additionally, cayenne supplements should not be used in conjunction with antacids, theophylline, blood thinners and aspirin.


