Progesterone, a female hormone, may be prescribed for you if you have experienced low progesterone levels as shown in your laboratory blood results. Progesterone in the 12.5-mg dose usually is prescribed to help regulate your menstrual flow. Side effects may occur from taking progesterone.
Bloating
Progesterone may induce edema or bloating of your ankles or feet, MayoClinic.com reports. You may notice your shoes do not fit as well. You'll need to report any changes since you started the hormone therapy to your doctor for continued evaluation and treatment.
Abdominal Pain
Abdominal pain may occur as a common and non-serious side effect of progesterone. You may experience this effect when you start this new hormone replacement therapy. Call your practitioner and tell her about this common side effect if it continues or becomes severe. Otherwise, it should cease as your body gets used to the progesterone.
Dizziness
You may experience dizziness as a common side effect of progesterone. As with all hormone therapy, your body needs time to adjust. Remain careful and get rest if you experience this side effect. Dizziness is not considered a serious side effect, but if you do not take care during movement, you could fall and hurt yourself. Report this side effect to your doctor only if it persists.
Mood Changes
Mood changes may occur. You may feel happy and then sad within the same hour. This up and down feeling could affect your behavior as well. You should tell your doctor about this side effect if it lingers, because he may need to change the dosage or type of hormone replacement.
Nervousness
As you start your treatment with progesterone, you may feel nervous or anxious. You may feel panicky and worried. Speak to your practitioner about this common side effect if it does not cease on its own.


