The female replacement hormone progesterone helps to prevent problems with the lining of your uterus. Overgrowth of the lining is protected with this hormone. Other uses include its regulation factor for your menstruation and ovulation cycles each month. Side effects may occur, Drugs.com reports. Before you start any new supplement or medication talk to your doctor.
Diarrhea
You may experience diarrhea as a side effect of taking progesterone tablets, Drugs.com indicates. Your stomach and digestive system may become irritated. Take your tablet with food. This may help prevent the side effect of diarrhea. If you continue to experience diarrhea, such as frequent loose stools, call your medical practitioner.
Stomach Cramps
Stomach cramps may occur as a result of taking progesterone, Drugs.com reports. This side effect may go away when you become used to this new medication. Call your doctor if this side effect continues.
Joint Pain
You may experience pain in your joints when you ingest progesterone, Medline Plus reports. Your joints may feel inflamed. You should talk to your doctor about treatment for this side effect. If this side effect does not go away on its own see your doctor. Joint pain could interfere with your activities of daily living.
Weight Changes
Weight changes may occur as a result of taking this new hormone, Medline Plus reports. You may develop weight gain and feel tired along with it. This should go away after a week or so as your body becomes accustomed to the hormonal changes.
Vaginal Discharge
You may discover you produce a vaginal discharge as a result of taking a hormone such as progesterone, Drugs.com states. You may notice your vaginal area has a slight odor difference. If the odor becomes foul and the discharge changes color, call your doctor as you may have a vaginal infection.
Breast Tenderness
As with any infusion of a hormone, your may discover you feel tenderness in your breasts as a side effect of progesterone, Medline Plus reports. Your breasts may feel tender to touch and just lying on them to sleep may bother you. If this tenderness does not go away on its own, speak with your doctor.
Headaches
Headaches may occur as a result of hormonal changes brought about by taking progesterone tablets, Medline Plus reports. You may need to rest more as you become used to the hormonal replacement of progesterone. Call your doctor if this side effect becomes bothersome or intolerable. A sudden or severe headache could signify a worse health issue.
Weakness
Weakness on one side of your body may occur as a serious side effect of progesterone use, RxList.com notes. This side effect requires you to call for help and seek medical attention at the local emergency room. Any one-sided weakness may indicate a stroke.
Balance and Speech Difficulties
Balance and speech difficulties also may signify a stroke when you use progesterone, RxList.com reports. You may experience neurological changes that require medical intervention quickly. Go to the emergency room if this serious side effect occurs.


