Prednisolone sodium phosphate is a corticosteroid drug. This compound mimics hormones that are naturally produced in your body, causing your hormone levels to rise and suppressing inflammation. Prednisolone sodium phosphate is commonly used to treat severe allergies, asthma and arthritis, but it also can be used for blood disorders and skin conditions such as rashes. Prednisolone sodium phosphate is an effective drug when taken in drug formulations in safe doses. The material safety data sheet (MSDS) for the pure compound specifies any hazards associated with direct exposure.
Properties
Prednisolone sodium phosphate is a white, slightly yellow powder. The chemical name is pregna-1,4-diene-3,20- dione, 11,17-dihydroxy-21-(phosphonooxy)- disodium salt, (11β)-. The chemical formula is C21H27Na2O8P and the molecular weight is 484.39 g per mole. Prednisolone sodium phosphate is soluble in cold water and methanol, and slightly soluble in acetone.
Hazards
Prednisolone sodium phosphate irritates the skin and eyes if direct contact is made. It also has acute health effects when ingested or inhaled. No chronic carcinogenic, mutagenic, teratogenic, or developmental effects are reported on the MSDS. Medical conditions have not been shown to be aggravated through prolonged or repeated exposure to prednisolone sodium phosphate.
First-Aid Measures
In the case of contact with eyes, remove contact lenses if present and flush eyes with running water for at least 15 minutes. Make sure to keep eyelids open and rinse thoroughly. The water can be cold. Do not use eye ointments and seek medical attention. In the case of accidental contact with skin, immediately wash the contaminated area with water. The water can be cold. A non-abrasive soap also should be used. Pay special attention to creases, crevices, folds and the groin area. Use an emollient to cover the irritated skin and seek medical attention if irritation persists. Wash any contaminated clothing before reuse.
In the case of serious skin contact, wash the area with a disinfecting soap and cover the contaminated skin with an anti-bacterial cream. Seek immediate medical attention.
If inhaled, remove the victim to a well-ventilated area and seek medical attention immediately.
If ingested, do not induce vomiting. Loosen any tight clothing such as belts, waistbands, collars, or ties. Perform mouth-to-mouth resuscitation if the victim is not breathing and seek medical attention immediately.
Handling and Storage
At high temperatures, prednisolone sodium phosphate can be combustible. Keep this chemical away from heat, sources of ignition and strong oxidizing agents. Keep containers tightly closed and store in a well-ventilated, dry, cool place. In the event of a small fire, use a dry chemical powder. In the event of a large fire, do not use a water jet. Use a water spray, foam or fog. When finished with a container, evaporate any remaining residue in a fume hood. Ground all equipment containing the material.
Wear suitable protective clothing when handling prednisolone sodium phosphate. Take care not to breathe in dust. Wear suitable respiratory equipment if you are in an area of insufficient ventilation. If symptoms persist, seek medical attention and show health care workers the label.
In the event of a small spill, put the spilled solid in a convenient waste disposal container using the appropriate tools. Spread water on the contaminated surface and check local and regional authority requirements for proper disposal. In the event of a large spill, put the solid into a convenient waste disposal container using a shovel. Spread water on the contaminated surface and allow to evacuate through the sanitary system.
Exposure Controls
Keep airborne levels below the recommended exposure levels by using local exhaust ventilation and/or process enclosures. In the case of user-generated dust, mist or fume, keep exposure to airborne contaminants below the exposure limit with ventilation.
Use personal protective equipment in the case of exposure. This includes splash goggles, a lab coat, a dust respirator, an approved/certified respirator and gloves.
In the case of a large spill, use personal protective equipment including splash goggles, a full suit, boots, a dust respirator, gloves, an approved/certified respirator and a self-contained breathing apparatus to avoid inhalation. Before handling any large spills, consult a specialist to determine if this protective equipment is sufficient.
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