PABA occurs naturally in your intestines and is a component of folic acid, a B-complex vitamin necessary for production of new cells. Also known as para-aminobenzoic acid or 4-aminobenzoic acid, PABA is found in liver, kidney, brewer's yeast, molasses, whole grains, mushrooms and spinach, and is available as a supplement or by prescription. PABA, in oral form, has been used to treat skin disorders and is a constituent of some sunscreens. Like all drugs and supplements, PABA has side effects that are mainly dose-related.
Possible PABA Deficiency
PABA is not considered to be an essential nutrient for human beings. Nonetheless, a PABA deficiency may play a role in a wide variety of problems including anemia, depression, nervousness, constipation, anxiety, irritability and fatigue. PABA is important to skin health, and a deficiency can lead to moist eczema and possibly an uneven pigmentation condition known as vitiligo. Because PABA aids in preserving hair color, some people blame insufficient PABA for premature graying.
Oral PABA Supplements
PABA has been used to treat the skin diseases scleroderma, dermatitis herpetiformis, dermatomyositis and Peyronie's disease. PABA's ability to attract oxygen enables the skin to better utilize oxygen and has led to improvement in some patients. PABA has been reported to repigment skin in some people with vitiligo. Side effects include upset stomach, diarrhea, nausea and poor appetite. Uncommon allergic reactions include rash, swelling, itching, dizziness and breathing problems. Rarely PABA can cause hypoglycemia, or low blood sugar.
PABA in Sunscreens
PABA's ability to absorb ultraviolet radiation makes it an effective sunscreen agent. PABA was one of the first sunscreen agents developed and is still used around the world. However, a few people -- 1 to 2 percent -- have a photo-allergic reaction to PABA, says NutritionalSupplementsHealthGuide.com. If you are one of these people, you can develop acne, dark red spots, burning, itching and painful skin blisters. If you stop using the PABA sunscreen, however, these side effects go away quickly.
PABA Drug Interactions and Overdosing
PABA can interact with certain medications. Do not take PABA if you are taking sulfa drugs. Do not take more than 400 mg per day of PABA; excessive doses can cause liver damage. Supplements containing large amounts of PABA have been banned. eVitamins.com reports that very large doses of PABA have led to deaths in children. As with all medications and supplements, talk with your doctor before using them and tell her about any allergies or other health problems you may have.



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