Thiazolidinediones describe a class of drugs used to treat diabetes mellitus (type 2 diabetes). Type 2 diabetes results when the body is unable to properly regulate sugar levels in the blood. Currently, two thiazolidinediones are available: rosiglitazone and pioglitazone. Both enable the body to better use insulin, a chemical that is normally released by the pancreas and manages sugar storage.
Contraindications
Certain medications should not be taken in conjunction with thiazolidinediones. Let your doctor know if you are taking or will be taking insulin, Singulair, nitrates (commonly prescribed for congestive heart failure) or rifampin. If you used to take troglitazone (a thiazolidinedione no longer prescribed in the U.S.) and experienced any side effects, mention that too.
Notify your doctor if you have liver disease or a diabetes-associated eye disease.
Thiazolidinediones may increase the chances of becoming pregnant. If you become pregnant or plan to breast-feed, speak with your doctor.
Common Side Effects
The most common side effects thiazolidinedione users report include fatigue, difficulty breathing, tightness/pain in chest, soreness in muscles and symptoms of a cold (fever, sore throat, sneezing, runny nose, cough).
Less Common Side Effects
Rare side effects include weight gain, changes in skin color, atypical bleeding and bruising, and swelling in extremities not due to injury.
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