The Effects Of Yohimbine Hcl

Yohimbine hydrochloride is a standardized extract from the African yohimbe tree, whose bark has been used for generations to improve male sexual performance. James Duke, Ph.D., author of "The Green Pharmacy," states that yohimbine HCL was developed in response to the high incidence of undesirable side effects -- such as high blood pressure, palpitations and agitation -- that occurred with traditional preparations of yohimbe bark.

Activates Neurotransmitters

Yohimbine HCL exerts its effects by stimulating the release of neurotransmitters in your nervous system. The "Physicians' Desk Reference for Herbal Medicines" reports that alpha-yohimbine, one of yohimbe's principal active constituents, selectively blocks nerve receptors that prevent the release of epinephrine and norepinephrine, thereby increasing the levels of these chemical messengers in brain centers and specific peripheral nerves.

Treats Erectile Dysfunction

According to a 2001 review in "World Journal of Urology," yohimbine demonstrates a "remarkable positive effect on sexual performance" in animal studies, and it is more effective than placebo for treating sexual dysfunction in men. A 1997 study reported in "International Journal of Impotence Research" showed that yohimbine HCL improved sexual desire, satisfaction, frequency of sexual contacts and quality of erection in men with erectile dysfunction. The drug was also well tolerated in this trial.

Side Effects

A prominent side effect of yohimbine, particularly when it is used for prolonged periods of time, is elevated blood pressure. Other potential side effects include agitation, trembling, rapid heartbeat and palpitations, insomnia, headache, dizziness, confusion, frequent urination and increased salivation. Priapism -- a condition characterized by prolonged, painful erections -- occasionally occurs as a result of yohimbine's actions on penile blood vessels. According to a 2009 case report in "Journal of Medical Toxicology," priapism may require surgical treatment.

Considerations

Yohimbine HCL is approved by the U.S. Food and Drug Administration for treating erectile dysfunction resulting from psychological issues, diabetes or other vascular diseases. However, more widely available and better-studied drugs are typically prescribed for treatment of this problem. If you think you could benefit from yohimbine HCL, talk to your physician about its risks, benefits and potential drug interactions.