Amitriptyline is the generic name for the antidepressant marketed in the United States as Elavil or Vanatrip. It is a "tricyclic" medication, meaning it works on three brain neurotransmitters associated with depression: serotonin, norepinephrine and dopamine. According to Mayo Clinic staff, abnormalities in these brain chemicals affect mood and behavior. Amitriptyline slows reabsorption of neurotransmitters to help relieve depression symptoms by keeping them in balance. Tricyclic antidepressants were one of the earliest antidepressants used to fight depression, but they can have many side effects.
Behavioral Side Effects
Behavioral side effects from taking amitriptyline include agitation, irritability and an increase in the very depression it was meant to assuage. According to Mayo Clinic staff, the drug may inspire suicidal thoughts, confusion, unrealistic beliefs, nervousness and excitability. Fear, hostility, lethargy and insomnia can also occur.
Nervous System and Muscular Side Effects
Nervous system and muscular side effects of taking amitriptyline include seizures (convulsions), uncontrolled eye, tongue and jaw movements, blurred vision, shaking, tremors and muscle weakness according to Drugs.com. Muscle pain, numbness, sweating and bruising easily also are possible.
Stomach Problems
Stomach problems from taking amitriptyline include nausea, vomiting, tarry stools, constipation, stomach pain and increased hunger pangs, according to Mayo Clinic staff. Weight gain or loss may take place along with dry mouth or drooling.
Heart and Lung Side Effects
Heart and lung side effects caused by amitriptyline include trouble breathing, rapid or irregular heartbeat and fainting. Mayo Clinic staff list other side effects like chest pain, high or low blood pressure, shortness of breath and unusual breath odor.
Other Side Effects
Other side effects from amitriptyline include bleeding gums, trouble speaking, hearing loss, cough, chills and ear ringing. Changes in urine output and color, fever, loss of balance control and even coma are listed as further side effects by the Mayo Clinic.
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