Tamoxifen primarily treats estrogen receptor-positive breast cancer. It prevents invasive breast cancer via blocking estrogen activity. The National Institutes of Health (NIH) states that tamoxifen is also used to treat breast cancer that has spread, and limit the risk of future breast cancer in patients with ductal carcinoma in situ and in patients with familial history of cancer. Side effects of Tamoxifen treatment may include depression, fatigue, cancer, stroke, blood clots, symptoms of menopause and diminished sexual desire.
Stroke
A stoke may be a side effect of Tamoxifen treatment, according to the National Cancer Institute (NCI). This side effect may be minor or may involve a more serious stroke.
Cancer of the Uterus
The NCI notes that cancer of the uterus may be a result of Tamoxifen treatment. This side effect may cause symptoms like unusual vaginal bleeding, discharge and irregular periods.
Blood Clots in Lung
A blood clot in the lung or other areas of the body may occur with Tamoxifen use, according to the NCI.
Loss of Sexual Desire and Symptoms of Menopause
The National Institutes of Health has linked Tamoxifen use to a lower desire for sexual activity. This side effect may be linked to symptoms of menopause that may occur while taking Tamoxifen, including hot flashes and vaginal dryness, according to the National Cancer Institute.
Depression and Fatigue
Depression and fatigue may be side effects of Tamoxifen, notes the NIH.
Breast Cancer
Breast cancer risk may increase with Tamoxifen use, too, according to Health Day News. Tamoxifen raises the risk of getting a more aggressive cancer in the healthy breast by more than four times. The new cancers were estrogen receptor-negative. They occurred after five years or more of Tamoxifen treatment, according to Health Day News.
