B-12 is a unique vitamin. It is in a class of molecules known as cobalamins because of its content of cobalt. Vitamin B-12 is responsible for normal functioning of cellular and DNA synthesis and reproduction. It also aids the action of another B vitamin, folate. It is its interaction with DNA and folate that makes it important in reducing your cancer risk.
B-12 and Cancer
According to the Linus Pauling Institute, there is evidence suggesting that vitamin B-12 may reduce your risk of cancer. Since vitamin B-12 plays such an essential role in the synthesis of DNA, a deficiency may result in the body's inability to properly replicate cells. B-12 and folic acid work together to ensure proper cellular reproduction. A deficiency of vitamin B-12 makes your body unable to liberate and use folic acid.
B-12 and Folic Acid
Folic acid and vitamin B-12 work together, as many vitamins do. In order for DNA to be properly synthesized, both folic acid and vitamin B-12 must be present. Without vitamin B-12, folic acid is unusable by the body. Folic acid assures that DNA is correctly replicated. If it is not, cells may reproduce incorrectly, causing a mutation that may lead to cancer. Therefore, vitamin B-12 may decrease the risk of cancer development by influencing folic acid and DNA replication.
Breast Cancer
According to a study published in the "Journal of the National Cancer Institute," high levels of vitamin B-12 and folic acid may reduce the risk of breast cancer. This study analyzed the blood of 32,826 women and monitored the development of breast cancer. High levels of vitamin B-12 in the blood plasma were thought to help prevent the development of breast cancer.
Sources and Recommendations
Men and women need to take in 2.4 mcg of vitamin B-12 each day. The typical diet may be able to fulfill this requirement. Vitamin B-12 is found in eggs, meat and dairy. Vegetarians may be at risk of developing a deficiency. If you are a vegetarian, be aware of your vitamin B-12 intake. B-12 is also available as a supplement. Check with your doctor to be sure vitamin B-12 supplementation is safe for you.
References
- Linus Pauling Institute; Vitamin B-12; Jane Higdon, Ph.D.; March 2003
- National Institutes of Health Office of Dietary Supplements; Dietary Supplement Fact Sheet: Vitamin B-12
- Journal of the National Cancer Institute; Plasma Folate, Vitamin B-6, Vitamin B-12, Homocysteine and Risk of Breast Cancer; S.M. Zhang, et al.; March 5, 2003
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