Neem, or Azadirachta indica, is an evergreen tree found extensively in India. The stems, roots, leaves and young fruits of the tree are made into capsules, tablets, lotions, creams, soaps and shampoos and are used to treat a variety of conditions. The side effects and drug interactions of the herb have not been documented scientifically, although Drugs.com states that more than 0.2 mL of neem oil per kilogram of body weight can lead to toxic reactions. It is important to talk to a doctor before using neem for any health problem.
Infections
Neem oil has significant antimicrobial activity against a variety of bacteria and fungi. A study published in the May 2007 edition of the "Malaria Journal" found that neem oil can inhibit the growth of the mosquito species that carry the malarial parasite and may be a cheap alternative to the traditional larvicides. Drugs.com also states that neem leaf extracts can improve hemoglobin and CD4+ in HIV patients without the help of any other anti-retroviral drugs. Neem extracts may also help treat sexually transmitted diseases in women caused by organisms such as Neisseria gonorrhea and Chlamydia trachomatis.
Cancer
Certain components of neem, such as limonin glucopyranoside, azadirone, quercetin and kaemferol, may suppress the growth of cancer cells and reduce the incidence of tumors by enhancing immune response, neutralizing free radicals and inhibiting division of cancer cells, says Drugs.com. These claims, however, have not been proven in actual clinical cases.
Dental Health
Neem twigs are commonly chewed every morning in rural India to clean the teeth and prevent dental infections. Several studies, such as the one published in 2007 in the "Indian Journal of Dental Research," have also demonstrated the inhibitory effects of neem extracts against oral bacteria such as Streptococcus mutans and Streptococcus salivarus, thereby proving the benefit of chewing neem twigs.
Anti-inflammatory and Analgesic Properties
Another study published in the June 2002 edition of the journal "Current Science" indicates that the chloroform extracts of neem stem bark can reduce inflammation in animal models. Neem plant extracts can also relieve pain via brain and spinal cord receptors known as opioid receptors. However, there is no clinical evidence to prove these benefits, so it is important to talk to a doctor before using them for pain.
Diabetes
Neem leaf extracts and neem seed oil helped reduce the blood sugar levels in diabetic rabbits, according to P. Khosla, author of a study published in the January 2000 edition of the "Indian Journal of Physiology and Pharmacology." Neem extracts may, therefore, help manage blood sugar levels in diabetes patients and delay the onset of the disease. However, it is important to prove these benefits in clinical cases before using them for diabetes treatment.
Head Lice
An article published in the September 2006 edition of the journal "Parasitology Research" states that shampoos containing neem are very effective against head lice in the laboratory and may replace some of the chemicals used in anti-lice shampoos. However, as in other cases, talk to your doctor before using neem shampoos for head lice to avoid adverse reactions.
References
- Drugs.com: Neem
- "Malaria Journal"; Larvicidal Effects of a Neem (Azadirachta indica) Oil Formulation on the Malaria Vector Anopheles Gambiae; Fredros Okumu, et al.; May 2007
- "Indian Journal of Dental Research"; The Effect of Mango and Neem Extract on Four Organisms Causing Dental Caries: Streptococcus Mutans, Streptococcus Salivavius, Streptococcus Mitis and Streptococcus Sanguis: An In Vitro Study; G.M. Prashant, et al.; October-December 2007
- "Current Science"; Biological Activities and Medicinal Properties of Neem (Azadirachta Indica); Kausik Biswas, et al.; June 2002
- "Indian Journal of Physiology and Pharmacology"; A Study of Hypoglycaemic Effects of Azadirachta Indica (Neem) in Normal and Alloxan Diabetic Rabbits; P. Khosla, et al.; January 2000
- "Parasitology Research"; A New Shampoo Based on Neem (Azadirachta indica) is Highly Effective Against Head Lice In Vitro ;Jörg Heukelbach, et al; September 2006



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