Your muscles, nerves and bones all rely on vitamin D to develop properly and maintain their normal function. As an adult, even if you get the recommended 600 to 800 international units of vitamin D daily, you may still be at risk of developing a vitamin D deficiency -- especially if you're taking certain drugs. Before beginning treatment with a new medication, talk with your doctor about how this drug may affect your vitamin levels.
Mineral Oil
Mineral oil is a type of lubricant laxative that helps reduce symptoms of bowel movement irregularity and constipation. Unfortunately, mineral oil can also interfere with your body's ability to absorb vitamin D from ingested foods or supplements.
Orlistat
Orlistat is an over-the-counter weight management drug that helps people lose weight by preventing the body from absorbing fat. As a fat-soluble nutrient, vitamin D may also not be absorbed by your body if you take this weight-loss drug.
Antacids
Antacids are a common drug used to alleviate heartburn or stomach indigestion. When used for prolonged periods of time, antacids may interfere with the way your body metabolizes vitamin D, thereby depleting vitamin D levels in your body.
Anti-seizure Medications
A class of medications called anti-seizure drugs may decrease levels of vitamin D in your body. Such medications include phenytoin, primidone, phenobarbital and valproic acid. If you take any of these drugs, you may also need to add a vitamin D supplement to your diet.
Bile Acid Sequestrants
If you have high cholesterol, your doctor may recommend treatment with a type of cholesterol-lowering drug called a bile acid sequestrant. Despite the benefits this class of medications may have on your heart health, taking these drugs may reduce your vitamin D levels. Examples of bile acid sequestrants include cholestripol and cholestyramine.
Rifampin
Rifampin is a medication used to treat tuberculosis, a type of severe bacterial infection. While receiving treatment with rifampin, you'll probably need to increase your vitamin D intake because this medication decreases vitamin D levels.



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