5-hydroxytryptophan -- called 5-HTP for short -- is a derivative of the amino acid tryptophan, and your body produces it naturally. This chemical helps boost the levels of serotonin, a mood-balancing chemical, in the brain. Thus, treatment with 5-HTP may be beneficial for people with conditions associated with low serotonin levels, such as depression, sleeping difficulties, hot flashes and migraines. However, more research is needed to examine these purported health benefits of 5-HTP. Only a medical professional who is familiar with your complete medical history can recommend the appropriate dosage of 5-HTP for you.
Dosing Recommendation
Adults can take 50 mg of 5-HTP up to three times daily, health professionals with the University of Maryland Medical Center report. Depending on your health status, your doctor may recommend taking a higher dose of this supplement. You shouldn't use high doses of 5-HTP without a doctor's guidance because such treatment may be toxic.
Contraindications
Despite the beneficial properties of 5-HTP, treatment with this supplement isn't right for everyone. The safety and effectiveness of 5-HTP during pregnancy hasn't been evaluated by the U.S. Food and Drug Administration. Thus, pregnant and breast-feeding women shouldn't use 5-HTP. Avoid treatment with this supplement if you have liver disease, Down syndrome or are scheduled to undergo surgery within the next two weeks.
Medication Interactions
Treatment with 5-HTP may interact with certain medications. Do not take 5-HTP if you're taking antidepressants because this treatment combination may elevate your risk of developing serotonin syndrome -- a condition that may cause blood pressure or heart rate changes or a coma. Other medications to avoid while taking 5-HTP include carbidopa, triptans and tramadol.
Adverse Effects
Mild adverse side effects may arise while you're taking 5-HTP. This supplement may cause nausea, vomiting, heartburn, bloating, stomach pain or diarrhea. You may also feel unusually tired or may experience a decrease in your normal sexual libido. Rarely, treatment with 5-HTP may cause a potentially life-threatening condition called eosinophilic myalgia syndrome. Seek emergency medical care if you exhibit symptoms of EMS, including skin rash, muscle pain and stiffness, breathing difficulties, joint pain, fatigue or hair loss.
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