Excedrin Migraine contains a combination of active ingredients that work together to reduce pain caused by tension headaches, migraine headaches, muscle aches, menstrual cramps, arthritis, toothaches and/or nasal congestion, as indicated by Drugs.com. The combination of ingredients treat the different factors that contribute to specific aches and pains.
Acetaminophen
Drugs.com explains that acetaminophen reduces pain and fever. Excedrin.com discloses that 250 mg of acetaminophen are included in each tablet of medication.
Aspirin
Aspirin, according to Drugs.com, belongs to a family of drugs called salicylates. These medications reduce chemicals in the body that cause pain, inflammation and fever. Excedrin.com shows 250 mg of aspirin in each tablet.
Caffeine
The addition of caffeine to Excedrin Migraine promotes the relaxation of muscle contractions. Drugs.com indicates that the relaxation allows blood flow to improve as the vessels will no longer be constricted. The caffeine can also stimulate the central nervous system. Each tablet contains 65 mg of caffeine, according to Excedrin.com


