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Can You Take Fish Oil With Lisinopril?

author image Adam Cloe
Adam Cloe has been published in various scientific journals, including the "Journal of Biochemistry." He is currently a pathology resident at the University of Chicago. Cloe holds a Bachelor of Arts in biochemistry from Boston University, a M.D. from the University of Chicago and a Ph.D. in pathology from the University of Chicago.
Can You Take Fish Oil With Lisinopril?
Close-up of a fish oil capsule in front of a large pill container. Photo Credit luchschen/iStock/Getty Images

High blood pressure puts extra strain on your heart, which can cause heart failure, and also increases your risk of developing atherosclerosis. High blood pressure can be treated with prescription medications, such as lisinopril, as well as over-the-counter supplements, such as fish oil. Fish oil can be taken along with prescription drugs such as lisinopril, but you should talk to your doctor before taking any supplements.


Lisinopril is an angiotensin converting enzyme inhibitor, PubMed Health reports. Angiotensin is a hormone that causes blood vessels to constrict when it is converted by the protein angiotensin converting enzyme, or ACE. This constriction of the blood vessels causes blood pressure to increase, so lisinopril and other angiotensin converting enzyme inhibitors are typically prescribed for people with high blood pressure. This medication must be taken every day to be effective. Your doctor will probably start you on a low dose and then gradually increase your dose.

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Fish Oil

Fish oil is a supplement rich in a type of unsaturated fat known as omega-3 fatty acids. You may take fish oil or other omega-3 fatty acid supplements, such as flaxseed oil, if you have an increased risk of heart disease. Fish oil is very effective at lowering levels of triglycerides, a type of lipid associated with heart disease. It also can lower blood pressure, MayoClinic.com notes, though high doses are typically needed to have a significant effect.


According to Drugs.com, there are no documented interactions between fish oil supplements and lisinopril. This means that there are no studies that have found an adverse effects from taking the two substances at the same time. On the other hand, because both lisinopril and fish oil can lower your blood pressure, there is the possibility that taking the two compounds together could cause your blood pressure to be too low, MedlinePlus states. Fish oil is not particularly effective at lowering blood pressure, so this risk is relatively small.


You should always tell your doctor about any supplements that you are taking, including fish oil, because over-the-counter supplements and vitamins can interfere with the effectiveness of some drugs.

The amount of omega-3 fatty acids in different kinds of fish oil can vary depending on the product, and high doses of fish oil can increase your risk of bruising or bleeding easily.

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