Geodon, an anti-psychotic medication indicated for use in schizophrenia and bipolar mania, blocks stimulation of serotonin and dopamine receptors in the brain. Effects on other receptors in the brain are thought to be responsible for the side effects of the drug.
Cardiac Arrhythmias
Geodon has been shown to cause QTc prolongation, which is a measure of heart function measured by an EKG. If you have a history of arrhythmias, or an abnormal heartbeat, you should be screened with an EKG prior to starting therapy, as Geodon can cause potentially fatal cardiac rhythms to develop.
Extrapyramidal Effects
Extrapyramidal side effects (EPS) are disorders of movement similar to those found in patients suffering from Parkinson's disease. These generally appear as uncontrollable, uncoordinated movements or muscle spasms, particularly of the face and arm. Stopping the drug usually causes these symptoms to go away, however longer terms of treatment may cause permanent effects.
Weight Gain and Hyperglycemia
Through unknown mechanisms, drugs such as Geodon may increase the amount of glucose in your blood stream, leading to hyperglycemia and weight gain. Patients with a prior history of diabetes should have their blood sugars checked more often until glucose levels stabilize on treatment.
Neuroleptic Malignant Syndrome
All anti-psychotic medications have the ability to cause a potentially life-threatening condition called neuroleptic malignant syndrome (NMS). Symptoms of NMS include muscle rigidity and high fever. If left untreated, the mortality rate of NMS is significant. It is a rare risk inherent to anti-psychotic medications and can be treated if help is sought immediately. Go to the emergency room immediately if you notice these symptoms while taking Geodon.
Sedation
Geodon and drugs like it have effects similar to over-the-counter decongestants---they can cause some sedation. It is best to avoid driving, using heavy machinery or drinking alcohol while taking Geodon until you know how it affects you.



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