An estimated 1.3 million Americans suffer with the chronic inflammatory symptoms associated with rheumatoid arthritis, the Arthritis Foundation reports. Triggered by an overactive immune system response, rheumatoid arthritis causes the body to attack healthy joints, which results in joint damage and pain. While some people find the condition debilitating, others experience symptom-free days with supplements such as glucosamine sulfate and conventional medications. Talk to your doctor about your options.
Glucosamine
Glucosamine exists naturally in the joints and is purported to help promote cartilage formation to cushion and protect the bones and joints. Glucosamine supplements are derived from shellfish, such as crab, lobster and shrimp. Because sulfate acts as a carrier molecule of glucosamine, the two substances are often used in conjunction as a joint supplement for rheumatoid arthritis and other types of arthritis.
Efficacy
According to the Mayo Clinic, research done on humans shows glucosamine helps reduce swelling and pain among rheumatoid arthritis sufferers, although other studies show no anti-rheumatic effects, but some symptom improvement. Additional research is needed to determine whether the supplements are worth using.
Dosages
Glucosamine sulfate and combination formulas containing chondroitin -- a substance that is derived from shark and beef cartilage and is a natural partner to glucosamine because of its joint-health benefits -- are available in capsule, tablets and powdered forms over-the-counter. Common dosages of glucosamine include 1,500 mg daily. Unlike conventional pain medications for joint discomfort, results are slow. Some users see results after one month.
Safaety and Cautions
Never attempt to treat your rheumatoid arthritis with medications your doctor has not approved. Although glucosamine sulfate is an over-the-counter drug, some side effects may still exist, such as stomach discomfort, heartburn, nausea, constipation or diarrhea. Gluosamine sulfate may also increase your blood pressure as well as your blood glucose, cholesterol and triglyceride levels. The products might also be dangerous for people with allergies to shellfish.


