Resveratrol, a natural compound found in grapes and red wine, has received considerable scientific attention for its potential benefits in cancer, heart disease, diabetes, high blood pressure and other chronic illnesses in humans. However, most of these health claims are based on animal studies. In fact, little information is available about its effects on humans. The use of resveratrol supplements are also not without side effects. Therefore, consult with your doctor before you decide to use them.
Breast Cancer Risk
Resveratrol shares a common general structure with endogenous estrogen. These similarities allow resveratrol to bind to estrogen receptors in cells, thereby acting as estrogens biologically. The link between estrogen and breast cancer is strong. Estrogen has been found to stimulate cell proliferation in milk-producing glands in the breast where most breast cancers arise, according to one study at NYU Langone Medical Center. So, consuming resveratrol supplements may increase breast cancer risk in women who are genetically susceptible to this disease.
Drug Interactions
No drug interactions in humans have been reported. However, if you take warfarin or other blood-thinning medications, talk to your doctor before using resveratrol or any other nutritional supplements. This is because resveratrol or grape seed extract reduces the formation of blood clots, putting you at risk of bleeding.
Cytochrome P450 Enzyme
Resveratrol inhibits cytochrome P450 3A4 activity. The cytochrome P450 enzyme system is responsible for the metabolism of therapeutic drugs. In humans, inactivation of CYP3A4 can cause severe drug toxicity, leading to many health problems, according to the Linus Pauling Institute at Oregon State University.
Pregnancy and Lactation
Resveratrol supplements are generally safe at a wide range of intakes; however, their safety and effectiveness during pregnancy and lactation have not been studied. There is no safe amount of alcohol consumption for pregnant women. Therefore, you should avoid alcohol, including wine, during pregnancy and breastfeeding.
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