Metanx is a prescription vitamin combination used to lower homocysteine, an amino acid. Under normal circumstances, homocysteine is harmless; however, elevated levels can cause adverse health effects. Your body converts homocysteine to helpful substances with the help of B vitamins. According to its official website, Metanx is primarily used to lower homocysteine in patients with diabetic peripheral neuropathy, a problem with the nerves that carry information to and from the brain and spinal cord to the rest of the body.
L-methylfolate Calcium
Metanx contains 3 mg of L-methylfolate calcium, the bioactive form of folic acid, a B vitamin. Folic acid converts homocysteine to methionine, another amino acid. Lowering homocysteine levels is important since high levels are associated with heart disease. Some individuals have trouble converting folic acid to its more active form, so providing the active form bypasses the need for conversion and helps your body lower homocysteine.
Pyridoxal 5-phosphate
Metanx contains 35 mg of Pyridoxal 5-phosphate, or P5P, the bioactive form of pyridoxine or vitamin B-6. P5P converts homocysteine to cystathionine and then to cysteine, an amino acid. Cysteine, along with methionine, act as antioxidants, chemicals that protect against free radical damage, harmful compounds with an unpaired number of electrons. Produced naturally from the production of energy, these molecules can damage cells, tissue and DNA while seeking to pair up.
Methylcobalamin
Metanx contains 2 mg of methycobalamin, an active form of B-12. Vitamin B-12 is available in several forms and is collectively known as cobalamin because it contains the mineral cobalt. Methylcobalamin helps accelerate the conversion of homocysteine so it does not build up in your blood. Methylcobalamin also helps protect DNA from damage.
Safety and Precautions
It is important to use Metanx exactly as your doctor directs. Metanx can interact with other vitamins or supplements. Consult your doctor before taking additional supplements. If you become pregnant, discuss the potential risks with your doctor. Side effects include drowsiness, numbness, tingling and mild diarrhea. Consult your doctor if you experience any lasting or severe side effects.
References
- Metanx: Metanx Quick Facts
- Drugs: Metanx
- University of Maryland Medical Center: Cysteine
- "Oregon State University"; Linus Pauling Institute; Folic Acid; Jane Higdon, Ph.D.; April 2002
- "Oregon State University"; Linus Pauling Institute; Vitamin B-6; Jane Higdon, Ph.D.; February 2002
- "Oregon State University"; Linus Pauling Institute: Vitamin B-12; Jane Higdon, Ph.D.; March 2003
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