Statin medications, used to treat high cholesterol, are associated with several significant side effects and drug interactions. The most common side effects associated with these drugs include muscle pain, liver damage, digestive upsets, rashes and neurological problems. Many products can increase the risk of side effects from these popular prescription medications. Herbal supplements such as grape seed extract could theoretically cause similar problems. However, no studies have evaluated statins' safety when combined with grape seed products.
Grape Seed Extract Explained
Grape seeds contain compounds known as oligomeric proanthocyanidin complexes, or OPCs, which appear to possess medicinal properties. According to the University of Maryland Medical Center, OPCs act as potent antioxidants, or compounds that protect living cells from reactive oxygen molecules. Because of grape seed extract's antioxidant capacity, the UMMC speculates that it may defend against edema, venous insufficiency, high cholesterol, hypertension, diabetes, and some forms of cancer. These medicinal effects could theoretically complement the effects of statins, which are known to reduce cholesterol and heart disease risk.
Statin Interactions
Statin drugs are associated with several serious drug interactions. MayoClinic.com states that some antibiotic and antifungal drugs can cause dangerous side effects when coupled with statin medications. Statin users also report more muscle aches when using the medications alongside certain antidepressants and immunosuppressant drugs. The prescription drugs Cordarone, Lopid and Zocor are also inappropriate for people taking statins. Furthermore, statin drugs can interact with grapefruit and grapefruit juice, which can cause the body to metabolize too much of the medication. None of these drugs or compounds are found in grape seed extract.
Grape Seed Extract Interactions
The National Centers for Complementary and Alternative Medicine reports, "Interactions between grape seed extract and medicines or other supplements have not been carefully studied." No well-designed clinical trials have evaluated the safety of grape seed extract when used along with statins or any other prescription medications. There is no evidence to confirm or refute any claims of safety, danger or synergy when the two products are combined. The UMMC notes a theoretical interaction between grape seed extract and warfarin (Coumadin) but does not acknoweldge any other specific concerns regarding drug-supplement interactions.
Considerations
If you use statins and want to take grape seed extract, consult your health care provider for guidance. Although there is no evidence that statins interact with grape seed extract, your health care provider needs a comprehensive view of your health and the steps you take to maintain it. If you notice any side effects while using grape seed extract and statins, promptly inform your primary care physician. Understand that scientists do not yet know whether it is safe to combine the two products. Your health care provider's expert advice is essential for balancing the potential benefits and risks.
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