5-HTP is taken for conditions ranging from depression and obesity to fibromyalgia and migraines, although the effectiveness of this supplement is still under investigation. 5-HTP, produced in the body from the amino acid tryptophan, is then converted into the neurotransmitter serotonin, which regulates mood. In general, 5-HTP is a safe supplement, with mostly mild side effects. However, high doses of 5-HTP might put you at risk for serotonin syndrome, which could put you in a coma. Serotonin syndrome is caused by an excessive amount of serotonin in your body. It can be caused by consuming too much 5-HTP or by mixing lower doses of 5-HTP with other medications that increase your serotonin level. Always consult your doctor before taking 5-HTP or any other supplement.
Doses
A typically recommended dosage of 5-HTP is 50 mg taken from 1 to 3 times per day. Clinical studies have used higher doses, but the University of Maryland Medical Center doesn't recommend taking higher doses because of the risk of serotonin syndrome.
Who Shouldn't Use 5-HTP
As the University of Maryland Medical Center warns, 5-HTP shouldn't be taken by children or by women who are pregnant or nursing. If you have high blood pressure or diabetes, talk with your doctor before taking 5-HTP. Do not take 5-HTP if you are taking antidepressant medications, since it might boost the amount of serotonin in your body to dangerous levels. Do not take 5-HTP if you have liver disease.
Side Effects
Most of the side effects related to 5-HTP involve your digestive system. Heartburn, diarrhea, gas, nausea, vomiting and loss of appetite are possible side effects. More serious side effects include severe muscle pain, seizures and possible allergic reactions.
Possible Interactions
As mentioned, don't use 5-HTP without the permission of your doctor if you are taking antidepressants, because this can result in serotonin syndrome. Symptoms include mental changes, hot flashes, major fluctuations in blood pressure and heart rate and the possibility of coma. Types of antidepressants include SSRIs, tricyclics and monoamine oxidase inhibitors. Serotonin syndrome also could be a consequence of taking Tramadol for pain or triptans for migraines. A medication for Parkinson's disease, carbidopa, also might interact with 5-HTP and cause a severe skin condition.
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