Bipolar & 5 HTP

While supplements alone are not sufficient to treat bipolar disorder, some studies show that the chemical 5-HTP may have a beneficial effect on regulating certain symptoms of this often debilitating condition. Although further research is required, 5-HTP may be particularly useful in regulating mood and alleviating depressive symptoms, according to "Quick Access: Patient Information on Conditions, Herbs & Supplements."

Bipolar Disorder Facts

Bipolar disorder, also referred to as manic depression or manic depressive disorder, causes mood swings alternating between manic and depressive episodes. According to the National Institute of Mental Health, extreme variations in levels of energy, activity, sleep and behavior are common symptoms of bipolar disorder. Manic episodes result in feelings of extreme highs, irritability, invincibility, a decreased need for sleep, racing thoughts or risk-taking behaviors. Depressive episodes manifest in symptoms such as a lowered mood, lethargic, irritability, a loss of interest in previously enjoyable activities and, in some cases, suicidal thoughts or gestures. While there is no cure for bipolar disorder, treatments focused on stabilizing mood and alleviation of other symptoms usually help improve quality of life and well-being.

About 5-HTP

5-HTP, also known as 5-Hydroxytryptophan, is an important chemical synthesized by your body from the amino acid tryptophan. Your body cannot manufacture tryptophan; it must be obtained from dietary sources. 5-HTP plays a vital role in the formation of the mood-regulating neurotransmitter known as serotonin. According to the University of Maryland Medical Center, 5-HTP appears to have a beneficial effect on mood, sleep, anxiety and appetite. 5-HTP may have a beneficial effect on depressive episodes in bipolar disorder, says Dr. James Lake in his book, "Textbook of Integrative Mental Health Care."

Clinical Evidence

Several studies support the idea that 5-HTP is as effective as certain prescription antidepressants in alleviating mild to moderate depression, according to the University of Maryland Medical Center. Additionally, a review published in the June 1987 issue of the "Journal of Clinical Psychopharmacology" suggests that 5-HTP is beneficial for depressed patients and does not cause many adverse side effects. Another review published in the February 2000 issue of the "Alternative Medicine Review" states scientific evidence suggests that 5-HTP is helpful for depression, although further clinical studies are required.

Considerations

Tryptophan, used to make 5-HTP, is present in dietary sources such as turkey, chicken, milk and other dairy products, sunflower seeds and seaweed. You can also take a 5-HTP supplement or a multivitamin containing 5-HTP. Consult your doctor before taking any dietary supplements, especially if you are taking prescription medication or use herbal remedies. According to the University of Maryland Medical Center, you should avoid the use of 5-HTP if you take antidepressants; have high blood pressure, diabetes, liver disease; or are pregnant or nursing.