Although calcium D-glucarate is a source of calcium, it's the glucarate component of this compound that may have some health benefits, according to the Memorial Sloan Kettering Cancer Center. While there is some preliminary evidence of health benefits for calcium glucarate, there haven't been enough studies using people to recommend calcium glucarate supplements. It's found in a number of nutritious fruits and vegetables, however, and increasing your fruit and vegetable intake has proven health benefits.
Potential for Cancer Prevention
An animal study published in Anticancer Research in March 2010 found that calcium glucarate may inhibit oral cancer. Further research is necessary, however, to determine whether it has the same effect in people. An article published in Alternative Medicine Reviews in 2002 noted that preliminary animal research has shown potential for calcium glucarate limiting the risk of skin, lung, prostate, breast and liver cancers as well. Calcium D-glucarate may also help lower estrogen levels, which is beneficial in limiting the effects of hormone-related cancers.
Getting more calcium D-glucarate in your diet may help you keep your cholesterol levels under control. Glucaro-1,4-lactone, a product of calcium D-glucarate metabolism, may cause changes in the beneficial bacteria in rats' digestive tract that help limit their risk of high cholesterol, according to a study published in the Journal of Agricultural and Food Chemistry in 2014. If it has the same effect in humans, calcium D-glucarate might offer cardiovascular benefits.
A test tube study published in Cell Biology and Toxicology in April 2008 found that a combination of D-glucaro 1,4-lactone and the antioxidant resveratrol may help regulate the behevaior of platelets, the cells responsible for forming blood clots. Resveratrol is found in cranberries, blueberries, dark chocolate, grapes, peanuts, pistachios and wine. Further research is necessary to verify this effect in humans, as well as determine which compound offers benefits.
Eating lettuce, grapes, bean sprouts, apples, grapefruit and cruciferous vegetables like broccoli, Brussels sprouts and cabbage can help you increase your calcium D-glucarate levels because they contain glucaric acid. Oranges are also one of the better sources of this nutrient.
Although there aren't any reported side effects with the use of calcium D-glucarate, you should check with your doctor before adding them to your daily routine to make sure it would be safe for you. Avoid taking calcium D-glucarate supplements if you're taking birth control pills, hormone replacement therapy medications or the Parkinson's disease medication entacapone. Calcium D-glucarate may make these medications less effective.
- Memorial Sloan Kettering Cancer Center: Calcium Glucarate
- Alternative Medicine Review: Calcium-D-Glucarate
- University of Michigan Health System: Calcium D-Glucarate
- Anticancer Research: Calcium Glucarate Inhibits DMBA-induced Oral Carcinogenesis in the Hamster: Histomorphometric Evaluation
- Cell Biology and Toxicology: D-Glucaro 1,4-Lactone and Resveratrol as Antioxidants in Blood Platelets
- Journal of Agricultural and Food Chemistry: Alteration of Gut Bacteria and Metabolomes After Glucaro-1,4-Lactone Treatment Contributes to the Prevention of Hypercholesterolemia