Millions of Americans suffer from excessive weight and obesity. In addition to exercise and a healthy diet, many obese individuals may require the use of prescription medications to shed unwanted pounds. A number of prescription medications are marketed for weight loss, which act by various mechanisms. Meridia is one type of weight loss drug that has been approved by the Food and Drug Administration for the treatment of obesity.
Obesity
Sedentary lifestyles and poor dietary habits have made obesity a growing concern in America. According to the U.S. Center for Disease Control and Prevention in 2009, 33 states had an obese population of greater than 25 percent. Obesity is a major risk factor for the development of heart disease and metabolic disorders such as diabetes. In addition, excessive weight can have a negative impact on activity level, self image and mood. Although prescription drugs can assist with weight loss, they should be used in conjunction with proper exercise and healthy dietary habits.
Meridia
Marketed under the brand name Meridia by Abbott Laboratories, sibutramine hydrochloride monohydrate is approved by the U.S. Food and Drug Administration for the treatment of obesity in patients with a Body Mass Index (BMI) greater than 30. Sibutramine is also a recommended treatment for patients with a BMI greater than 27 if other risk factors are present such as diabetes, hypertension, or high cholesterol.
Dosing
Meridia exerts its weight loss effects by increasing the availability of stimulatory neurotransmitters such as norepinephrine, serotonin and dopamine. These neurotransmitters have the potential to stimulate activity and increase metabolism. The initial recommended dose for adults is 10 mg once per day. If tolerated and effective, the dose can be increased to 15 mg once daily after four weeks. A lower 5 mg dose is available for patients who cannot tolerate the 10 mg daily dose.
Safety
As with all stimulants, sibutramine can cause elevations in heart rate and blood pressure. Other serious side effects may include seizures and alterations in mood and behavior. Sibutramine can have an additive effect when used with other stimulatory medications and should be avoided with certain drugs. Sibutramine should be used with extreme caution in the elderly or patients with heart disease. Patients with concerns regarding the use of Meridia should speak to their physician.
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