5-hydroxytryptophan (5-HTP) is an herbal supplement derived from the Griffonia simplicifolia plant. As a natural source of tryptophan, 5-HTP is used in alternative medicine to treat serotonin-related symptoms like low mood and overeating. The effectiveness of 5-HTP for treating MDMA-induced depression has not been established. Learning more about 5-HTP allows you to make informed decisions about your own use of the supplement. To prevent health problems, always ask a physician before using 5-HTP.
Causes
MDMA, also known by the street name "ecstasy," is a psychedelic stimulant from the amphetamine family. MDMA produces its effects by binding to serotonin transporters and triggering excessive serotonin release from neurons. After the initial effects, MDMA can leave the brain depleted of serotonin. According to the National Institute on Drug Abuse, primates given MDMA for only four days experienced changes in serotonin levels that were present up to seven years later. Low serotonin levels have been linked to depression, anxiety and other mental health disorders.
Symptoms
MDMA can cause many unpleasant symptoms in users. The National Institute on Drug Abuse states that MDMA users may experience depression, insomnia, confusion and severe anxiety for days or weeks after using the drug. For some people, repeated use can cause lasting problems with memory and other cognitive functions. The duration and severity of symptoms depends on a number of factors, including dose, frequency of use and individual health status.
Effectiveness
It is not currently known whether 5-HTP is effective for MDMA-induced depression. According to the National Institutes of Health, rats given 5-HTP following MDMA use had higher serotonin levels than controls. It is not clear whether the supplement has any effect on depression itself or whether the results apply to humans. 5-HTP can cause unwanted effects in some users. Drug Information Online lists nausea, appetite loss, vomiting and stomach pain as possible side effects of 5-HTP. Like other herbal supplements, 5-HTP is not closely regulated and has not been approved by the FDA for certain uses.
Prevention/Solution
The only way to avoid MDMA-induced depression is to abstain from using it. Ask a doctor before adding 5-HTP to your supplement regimen. To help ensure quality, Drug Information Online recommends buying 5-HTP from trusted sources. Stop using 5-HTP immediately and consult a doctor if you experience persistent or bothersome side effects. Do not take 5-HTP with other drugs that increase serotonin, such as selective serotonin reuptake inhibitors or tricyclic antidepressants.
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