Detrol is a brand of the drug known as Tolterodine tartarate. The FDA approves the use of Detrol for use in cases of overactive bladder. Overactive bladder usually manifests as incontinence (an inability to hold in urine), an increased urgency to void, and more frequent need to go the bathroom.
According to the National Association for Continence, overactive bladder affects about one in five adults over 40 and increases in prevalence with age. Women are affected twice as often as men. An estimated 12.2 million adults suffer from this condition in the United States.
How Detrol Works
Bladder control depends on a balance between the factors that control emptying and those that cause the bladder to retain urine. In overactive bladder syndrome, the bladder-emptying mechanisms acquire the upper hand and lead to uncontrolled emptying of the bladder. The system of nerves controlling this mechanism is called the parasympathetic system. This effect is mediated through specific nerve endings called muscarinic receptors located in the Detrusor muscles of the bladder.
Information from the FDA indicates that Detrol blocks the muscarinic receptors, reducing the activity of the emptying system. This blockade relaxes the detrusor muscles and restores some bladder control. The person with overactive bladder finds it easier to make it to the restroom without embarrassment and sleeps better at night with less midnight dashes to the restroom while taking Detrol. The result is a huge relief and increased confidence in carrying out routine chores and social activities for the patient.
Uses and Limitations
Detrol comes in convenient long-acting formulations that require single doses or shorter-acting formulations to be taken twice daily. It is avoided in those who have a problem with urinary retention, glaucoma and diminished intestinal function.
Further evaluation of all cases of overactive bladder is encouraged before the use of this drug to determine its appropriateness.
