Acetyl L-carnitine is often promoted as a bodybuilding and weight loss supplement, with estimated global sales to reach $128 million by 2017, according to Global Industry Analysts Inc. Although little in the way of scientific research supports these claims, many people still seek out carnitine in hopes of giving them an edge in competition or in the workplace. Carnitine is generally safe for most people, but it does have potential side effects you should be aware of before adding it to your diet.
Identification
Carnitine is a nutrient your body produces in the liver and kidneys that's stored in your muscles, heart, brain and, for men, in sperm. It's needed to help convert fat into energy and to reduce oxidative stress, which occurs when harmful free radicals damage the interior walls and DNA in your cells. It might also have mind-boosting effects, leading to more alertness and energy. If you're like most people, your body makes all the carnitine it needs naturally, but a few health conditions might lead to a deficiency.
Body Odor
High doses of 3,000 mg or more per day might cause an unpleasant body odor. Researchers in France published a study in the April 2011 issue of "Revue Neurologique" reporting on a case in which carnitine supplementation led to a strong fishy smell in one patient. The problem resolved itself after the patient discontinued the carnitine.
Gastrointestinal Problems
More than 3,000 mg of carnitine per day can cause gastrointestinal problems, including nausea, vomiting, abdominal pain, cramps or diarrhea. Researchers using carnitine on patients with chronic fatigue syndrome published a report in "Neuropsychobiology" in 1997 stating that -- although carnitine was generally well-tolerated -- one patient was unable to complete the trial due to diarrhea.
Rashes
One of the milder side effects from carnitine at 5,000 mg or more per day is a skin rash. It's a rare side effect and should resolve itself when you stop taking the supplements. If you experience this symptom, and it doesn't get better after you stop taking carnitine, check with your doctor.
Seizures and Overstimulation
Overstimulation and anxiety can occur in carnitine doses above 500 mg. In a dosage over 1,000 mg, you might experience insomnia. Carnitine induced a seizure lasting up to four hours in a patient involved with a study published in "Neuropharmacology" in May 1984. The Linus Pauling Institute adds that Alzheimer's patients might be particularly sensitive to these effects, and that you should avoid taking carnitine if you have a history of seizures or a seizure disorder.
References
- University of Maryland Medical Center: L-Carnitine
- RaySahelian.com; "Acetyl L-carnitine"; Dr. Ray Sahelian
- "Neuropharmacology"; "Transient Seizure Activity Induced by Acetylcarnitine"; R.G. Fariello et al; May 1984
- Linus Pauling Institute; "L-Carnitine"; Jane Higdon and Victoria Drake; October 2002 and April 2007
- "Revue Neurologique"; "L-Carnitine Treatment and Fish Odor Syndrome: An Unwanted Adverse Effect"; F. Rocher et al; April 2011
- "Neuropsychobiology"; "Amantadine and L-carnitine Treatment of Chronic Fatigue Syndrome"; A.V. Plioplys and S. Plioplys; 1997



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