Selective serotonin reuptake inhibitors, or SSRIs, are medications used to treat clinical depression. SSRIs work by increasing the level of serotonin in your brain. According to the book "Integrative Medicine," SSRIs have shown effectiveness in reducing the symptoms of moderate to severe depression. SSRIs typically have fewer side effects compared to other classes of antidepressant drugs. Melatonin is a supplement you can purchase as a sleep aid. Melatonin supplements may affect the way SSRIs function in your body and may magnify certain side effects of SSRIs. The extent of these interactions, however, requires further clinical study. Exercise caution when using melatonin supplements with SSRIs.
Depression
Depression is a common disorder that is often misdiagnosed. A psychiatrist can properly diagnose and treat most depressive conditions. Feeling blue or down for a day or two is not depression. According to "Integrative Medicine," if you feel sad for a period of two weeks or more or have prolonged feelings of hopelessness, lethargy and a general lack of interest in participating in life socially, you might suffer from depression. Clinical depression is a serious condition that medical professionals can treat through therapy and medications such as SSRIs.
Melatonin
Your brain makes melatonin in the pineal gland from the amino acid tryptophan. Your brain naturally releases melatonin when it is dark outside and your body is not exposed to light. Your body produces the highest levels of melatonin right before you go to sleep. You can purchase a synthesized version of melatonin over-the-counter as a sleep aid.
Side Effects
According to the Mayo Clinic, SSRIs generally have few and mild side effects. However, one possible side effect of SSRIs is drowsiness, and taking melatonin can intensify this effect. SSRIs such as fluvoxamine may increase blood levels of endogenous melatonin, leading to increased drowsiness throughout the day. Every SSRI has a slightly different composition and when combined with your unique genetic makeup may have different results in different people.
Interaction
According to the University of Maryland Medical Center, in animal studies, melatonin supplementation reduced the effectiveness of SSRIs. It is not known if this animal studies apply to people. Additionally, since SSRIs can cause an increase in your body's melatonin levels, taking additional melatonin at the same time could cause excessive drowsiness. You should inform your doctor of all supplements you currently take, including melatonin.
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